Abstract

Discrimination between viral and self-derived nucleic acid species is crucial in maintaining effective antiviral immunity whilst avoiding autoinflammation. Ahmad et al. and Chung et al. delineate the consequences of MDA5 gain of function and loss of ADAR1 activity, highlighting the blurring of the concept of self and non-self when considering endogenous retroelements.

Original languageEnglish
Pages (from-to)640-642
Number of pages3
JournalCell
Volume172
Issue number4
DOIs
Publication statusPublished - 8 Feb 2018

Keywords

  • Journal Article

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