Sortase A contributes to pneumococcal nasopharyngeal colonization in the chinchilla model

Shu Chen, Gavin K Paterson, Hua Hua Tong, Timothy J Mitchell, Thomas F DeMaria

Research output: Contribution to journalArticlepeer-review

Abstract

Sortase A (SrtA) is required to anchor neuraminidase, beta-galactosidase, and possibly other LPXTG motif proteins to the pneumococcal cell surface. We examined the role of SrtA in Streptococcus pneumoniae nasopharyngeal (NP) colonization in the chinchilla model. The srtA mutant colonized the nasopharynx at a significantly lower level than the D39 parent strain during the second and third week of the carriage, and was eliminated from nasopharynx one week earlier than the D39 pneumococci. Our data indicate that SrtA contributes to pneumococcal NP colonization in this animal model.

Original languageEnglish
Pages (from-to)151-4
Number of pages4
JournalFEMS Microbiology Letters
Volume253
Issue number1
DOIs
Publication statusPublished - 1 Dec 2005

Keywords

  • Aminoacyltransferases/genetics
  • Animals
  • Bacterial Proteins/genetics
  • Cell Membrane/enzymology
  • Chinchilla
  • Cysteine Endopeptidases
  • Disease Models, Animal
  • Female
  • Genes, Bacterial
  • Humans
  • Male
  • Mutation
  • Nasopharynx/microbiology
  • Otitis Media/microbiology
  • Phenotype
  • Pneumococcal Infections/microbiology
  • Streptococcus pneumoniae/enzymology
  • Time Factors

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