Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment

Valerie P I Vidal; Marie-Christine Chaboissier; Susanne Lützkendorf; George Cotsarelis; Pleasantine Mill; Chi-Chung Hui; Nicolas Ortonne; Jean-Paul Ortonne; Andreas Schedl

doi:10.1016/j.cub.2005.06.064

Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment

Valerie P I Vidal, Marie-Christine Chaboissier, Susanne Lützkendorf, George Cotsarelis, Pleasantine Mill, Chi-Chung Hui, Nicolas Ortonne, Jean-Paul Ortonne, Andreas Schedl

Research output: Contribution to journal › Article › peer-review

Abstract

The mammalian hair represents an unparalleled model system to understand both developmental processes and stem cell biology. The hair follicle consists of several concentric epithelial sheaths with the outer root sheath (ORS) forming the outermost layer. Functionally, the ORS has been implicated in the migration of hair stem cells from the stem cell niche toward the hair bulb. However, factors required for the differentiation of this critical cell lineage remain to be identified. Here, we describe an unexpected role of the HMG-box-containing gene Sox9 in hair development.

Original language	English
Pages (from-to)	1340-51
Number of pages	12
Journal	Current biology : CB
Volume	15
Issue number	15
DOIs	https://doi.org/10.1016/j.cub.2005.06.064
Publication status	Published - 9 Aug 2005

Keywords

Alopecia
Animals
Carcinoma, Basal Cell
GATA3 Transcription Factor
Gene Expression Regulation, Developmental
Gene Silencing
Hair Follicle
Hedgehog Proteins
High Mobility Group Proteins
Immunohistochemistry
In Situ Hybridization
Mice
Mice, Transgenic
Microscopy, Electron, Scanning
SOX9 Transcription Factor
Signal Transduction
Skin Neoplasms
Stem Cells
Trans-Activators
Transcription Factors

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10.1016/j.cub.2005.06.064

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title = "Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment",

abstract = "The mammalian hair represents an unparalleled model system to understand both developmental processes and stem cell biology. The hair follicle consists of several concentric epithelial sheaths with the outer root sheath (ORS) forming the outermost layer. Functionally, the ORS has been implicated in the migration of hair stem cells from the stem cell niche toward the hair bulb. However, factors required for the differentiation of this critical cell lineage remain to be identified. Here, we describe an unexpected role of the HMG-box-containing gene Sox9 in hair development.",

keywords = "Alopecia, Animals, Carcinoma, Basal Cell, GATA3 Transcription Factor, Gene Expression Regulation, Developmental, Gene Silencing, Hair Follicle, Hedgehog Proteins, High Mobility Group Proteins, Immunohistochemistry, In Situ Hybridization, Mice, Mice, Transgenic, Microscopy, Electron, Scanning, SOX9 Transcription Factor, Signal Transduction, Skin Neoplasms, Stem Cells, Trans-Activators, Transcription Factors",

author = "Vidal, {Valerie P I} and Marie-Christine Chaboissier and Susanne L{\"u}tzkendorf and George Cotsarelis and Pleasantine Mill and Chi-Chung Hui and Nicolas Ortonne and Jean-Paul Ortonne and Andreas Schedl",

year = "2005",

month = aug,

day = "9",

doi = "10.1016/j.cub.2005.06.064",

language = "English",

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pages = "1340--51",

journal = "Current Biology",

issn = "0960-9822",

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TY - JOUR

T1 - Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment

AU - Vidal, Valerie P I

AU - Chaboissier, Marie-Christine

AU - Lützkendorf, Susanne

AU - Cotsarelis, George

AU - Mill, Pleasantine

AU - Hui, Chi-Chung

AU - Ortonne, Nicolas

AU - Ortonne, Jean-Paul

AU - Schedl, Andreas

PY - 2005/8/9

Y1 - 2005/8/9

N2 - The mammalian hair represents an unparalleled model system to understand both developmental processes and stem cell biology. The hair follicle consists of several concentric epithelial sheaths with the outer root sheath (ORS) forming the outermost layer. Functionally, the ORS has been implicated in the migration of hair stem cells from the stem cell niche toward the hair bulb. However, factors required for the differentiation of this critical cell lineage remain to be identified. Here, we describe an unexpected role of the HMG-box-containing gene Sox9 in hair development.

AB - The mammalian hair represents an unparalleled model system to understand both developmental processes and stem cell biology. The hair follicle consists of several concentric epithelial sheaths with the outer root sheath (ORS) forming the outermost layer. Functionally, the ORS has been implicated in the migration of hair stem cells from the stem cell niche toward the hair bulb. However, factors required for the differentiation of this critical cell lineage remain to be identified. Here, we describe an unexpected role of the HMG-box-containing gene Sox9 in hair development.

KW - Alopecia

KW - Animals

KW - Carcinoma, Basal Cell

KW - GATA3 Transcription Factor

KW - Gene Expression Regulation, Developmental

KW - Gene Silencing

KW - Hair Follicle

KW - Hedgehog Proteins

KW - High Mobility Group Proteins

KW - Immunohistochemistry

KW - In Situ Hybridization

KW - Mice

KW - Mice, Transgenic

KW - Microscopy, Electron, Scanning

KW - SOX9 Transcription Factor

KW - Signal Transduction

KW - Skin Neoplasms

KW - Stem Cells

KW - Trans-Activators

KW - Transcription Factors

U2 - 10.1016/j.cub.2005.06.064

DO - 10.1016/j.cub.2005.06.064

M3 - Article

C2 - 16085486

VL - 15

SP - 1340

EP - 1351

JO - Current Biology

JF - Current Biology

SN - 0960-9822

IS - 15

ER -

Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment

Abstract

Keywords

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