Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment

Valerie P I Vidal, Marie-Christine Chaboissier, Susanne Lützkendorf, George Cotsarelis, Pleasantine Mill, Chi-Chung Hui, Nicolas Ortonne, Jean-Paul Ortonne, Andreas Schedl

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The mammalian hair represents an unparalleled model system to understand both developmental processes and stem cell biology. The hair follicle consists of several concentric epithelial sheaths with the outer root sheath (ORS) forming the outermost layer. Functionally, the ORS has been implicated in the migration of hair stem cells from the stem cell niche toward the hair bulb. However, factors required for the differentiation of this critical cell lineage remain to be identified. Here, we describe an unexpected role of the HMG-box-containing gene Sox9 in hair development.
Original languageEnglish
Pages (from-to)1340-51
Number of pages12
JournalCurrent biology : CB
Volume15
Issue number15
DOIs
Publication statusPublished - 9 Aug 2005

Keywords / Materials (for Non-textual outputs)

  • Alopecia
  • Animals
  • Carcinoma, Basal Cell
  • GATA3 Transcription Factor
  • Gene Expression Regulation, Developmental
  • Gene Silencing
  • Hair Follicle
  • Hedgehog Proteins
  • High Mobility Group Proteins
  • Immunohistochemistry
  • In Situ Hybridization
  • Mice
  • Mice, Transgenic
  • Microscopy, Electron, Scanning
  • SOX9 Transcription Factor
  • Signal Transduction
  • Skin Neoplasms
  • Stem Cells
  • Trans-Activators
  • Transcription Factors

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