Spatial and temporal epidemiology of sporadic human cases of Escherichia coli O157 in Scotland, 1996-1999

Wellcome Trust-funded IPRAVE Consortium, G T Innocent, D J Mellor, S A McEwen, W J Reilly, J Smallwood, M E Locking, D J Shaw, P Michel, D J Taylor, W B Steele, G J Gunn, H E Ternent, M E J Woolhouse, S W J Reid

Research output: Contribution to journalArticlepeer-review

Abstract

In Scotland, between 1995 and 2000 there were between 4 and 10 cases of illness per 100000 population per year identified as being caused by Escherichia coli O157, whereas in England and Wales there were between 1 and 2 cases per 100000 population per year. Within Scotland there is significant regional variation. A cluster of high rate areas was identified in the Northeast of Scotland and a cluster of low rate areas in central-west Scotland. Temporal trends follow a seasonal pattern whilst spatial effects appeared to be distant rather than local. The best-fit model identified a significant spatial trend with case rate increasing from West to East, and from South to North. No statistically significant spatial interaction term was found. In the models fitted, the cattle population density, the human population density, and the number of cattle per person were variously significant. The findings suggest that rural/urban exposures are important in sporadic infections.
Original languageEnglish
Pages (from-to)1033-41
Number of pages9
JournalEpidemiology and Infection
Volume133
Issue number6
DOIs
Publication statusPublished - 2005

Keywords

  • Animals
  • Cattle
  • Disease Outbreaks
  • Escherichia coli Infections
  • Escherichia coli O157
  • HUMANS
  • Logistic Models
  • SCOTLAND

Fingerprint

Dive into the research topics of 'Spatial and temporal epidemiology of sporadic human cases of Escherichia coli O157 in Scotland, 1996-1999'. Together they form a unique fingerprint.

Cite this