Spatial and temporal epidemiology of sporadic human cases of Escherichia coli O157 in Scotland, 1996-1999

Wellcome Trust-funded IPRAVE Consortium; G T Innocent; D J Mellor; S A McEwen; W J Reilly; J Smallwood; M E Locking; D J Shaw; P Michel; D J Taylor; W B Steele; G J Gunn; H E Ternent; M E J Woolhouse; S W J Reid

doi:10.1017/S0950268805003687

Spatial and temporal epidemiology of sporadic human cases of Escherichia coli O157 in Scotland, 1996-1999

Wellcome Trust-funded IPRAVE Consortium, G T Innocent, D J Mellor, S A McEwen, W J Reilly, J Smallwood, M E Locking, D J Shaw, P Michel, D J Taylor, W B Steele, G J Gunn, H E Ternent, M E J Woolhouse, S W J Reid

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

In Scotland, between 1995 and 2000 there were between 4 and 10 cases of illness per 100000 population per year identified as being caused by Escherichia coli O157, whereas in England and Wales there were between 1 and 2 cases per 100000 population per year. Within Scotland there is significant regional variation. A cluster of high rate areas was identified in the Northeast of Scotland and a cluster of low rate areas in central-west Scotland. Temporal trends follow a seasonal pattern whilst spatial effects appeared to be distant rather than local. The best-fit model identified a significant spatial trend with case rate increasing from West to East, and from South to North. No statistically significant spatial interaction term was found. In the models fitted, the cattle population density, the human population density, and the number of cattle per person were variously significant. The findings suggest that rural/urban exposures are important in sporadic infections.

Original language	English
Pages (from-to)	1033-41
Number of pages	9
Journal	Epidemiology & Infection
Volume	133
Issue number	6
DOIs	https://doi.org/10.1017/S0950268805003687
Publication status	Published - 2005

Keywords / Materials (for Non-textual outputs)

Animals
Cattle
Disease Outbreaks
Escherichia coli Infections
Escherichia coli O157
HUMANS
Logistic Models
SCOTLAND

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10.1017/S0950268805003687

Spatial and temporal epidemiology of sporadic human cases of
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Wellcome Trust-funded IPRAVE Consortium, Innocent, G. T., Mellor, D. J., McEwen, S. A., Reilly, W. J., Smallwood, J., Locking, M. E., Shaw, D. J., Michel, P., Taylor, D. J., Steele, W. B., Gunn, G. J., Ternent, H. E., Woolhouse, M. E. J., & Reid, S. W. J. (2005). Spatial and temporal epidemiology of sporadic human cases of Escherichia coli O157 in Scotland, 1996-1999. Epidemiology & Infection, 133(6), 1033-41. https://doi.org/10.1017/S0950268805003687

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title = "Spatial and temporal epidemiology of sporadic human cases of Escherichia coli O157 in Scotland, 1996-1999",

abstract = "In Scotland, between 1995 and 2000 there were between 4 and 10 cases of illness per 100000 population per year identified as being caused by Escherichia coli O157, whereas in England and Wales there were between 1 and 2 cases per 100000 population per year. Within Scotland there is significant regional variation. A cluster of high rate areas was identified in the Northeast of Scotland and a cluster of low rate areas in central-west Scotland. Temporal trends follow a seasonal pattern whilst spatial effects appeared to be distant rather than local. The best-fit model identified a significant spatial trend with case rate increasing from West to East, and from South to North. No statistically significant spatial interaction term was found. In the models fitted, the cattle population density, the human population density, and the number of cattle per person were variously significant. The findings suggest that rural/urban exposures are important in sporadic infections.",

keywords = "Animals, Cattle, Disease Outbreaks, Escherichia coli Infections, Escherichia coli O157, HUMANS, Logistic Models, SCOTLAND",

author = "{Wellcome Trust-funded IPRAVE Consortium} and Innocent, {G T} and Mellor, {D J} and McEwen, {S A} and Reilly, {W J} and J Smallwood and Locking, {M E} and Shaw, {D J} and P Michel and Taylor, {D J} and Steele, {W B} and Gunn, {G J} and Ternent, {H E} and Woolhouse, {M E J} and Reid, {S W J}",

year = "2005",

doi = "10.1017/S0950268805003687",

language = "English",

volume = "133",

pages = "1033--41",

journal = "Epidemiology & Infection",

issn = "0950-2688",

publisher = "Cambridge University Press",

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Wellcome Trust-funded IPRAVE Consortium, Innocent, GT, Mellor, DJ, McEwen, SA, Reilly, WJ, Smallwood, J, Locking, ME, Shaw, DJ, Michel, P, Taylor, DJ, Steele, WB, Gunn, GJ, Ternent, HE, Woolhouse, MEJ & Reid, SWJ 2005, 'Spatial and temporal epidemiology of sporadic human cases of Escherichia coli O157 in Scotland, 1996-1999', Epidemiology & Infection, vol. 133, no. 6, pp. 1033-41. https://doi.org/10.1017/S0950268805003687

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T1 - Spatial and temporal epidemiology of sporadic human cases of Escherichia coli O157 in Scotland, 1996-1999

AU - Wellcome Trust-funded IPRAVE Consortium

AU - Innocent, G T

AU - Mellor, D J

AU - McEwen, S A

AU - Reilly, W J

AU - Smallwood, J

AU - Locking, M E

AU - Shaw, D J

AU - Michel, P

AU - Taylor, D J

AU - Steele, W B

AU - Gunn, G J

AU - Ternent, H E

AU - Woolhouse, M E J

AU - Reid, S W J

PY - 2005

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N2 - In Scotland, between 1995 and 2000 there were between 4 and 10 cases of illness per 100000 population per year identified as being caused by Escherichia coli O157, whereas in England and Wales there were between 1 and 2 cases per 100000 population per year. Within Scotland there is significant regional variation. A cluster of high rate areas was identified in the Northeast of Scotland and a cluster of low rate areas in central-west Scotland. Temporal trends follow a seasonal pattern whilst spatial effects appeared to be distant rather than local. The best-fit model identified a significant spatial trend with case rate increasing from West to East, and from South to North. No statistically significant spatial interaction term was found. In the models fitted, the cattle population density, the human population density, and the number of cattle per person were variously significant. The findings suggest that rural/urban exposures are important in sporadic infections.

AB - In Scotland, between 1995 and 2000 there were between 4 and 10 cases of illness per 100000 population per year identified as being caused by Escherichia coli O157, whereas in England and Wales there were between 1 and 2 cases per 100000 population per year. Within Scotland there is significant regional variation. A cluster of high rate areas was identified in the Northeast of Scotland and a cluster of low rate areas in central-west Scotland. Temporal trends follow a seasonal pattern whilst spatial effects appeared to be distant rather than local. The best-fit model identified a significant spatial trend with case rate increasing from West to East, and from South to North. No statistically significant spatial interaction term was found. In the models fitted, the cattle population density, the human population density, and the number of cattle per person were variously significant. The findings suggest that rural/urban exposures are important in sporadic infections.

KW - Animals

KW - Cattle

KW - Disease Outbreaks

KW - Escherichia coli Infections

KW - Escherichia coli O157

KW - HUMANS

KW - Logistic Models

KW - SCOTLAND

U2 - 10.1017/S0950268805003687

DO - 10.1017/S0950268805003687

M3 - Article

C2 - 16274499

SN - 0950-2688

VL - 133

SP - 1033

EP - 1041

JO - Epidemiology & Infection

JF - Epidemiology & Infection

IS - 6

ER -

Spatial and temporal epidemiology of sporadic human cases of Escherichia coli O157 in Scotland, 1996-1999

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Keywords / Materials (for Non-textual outputs)

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