Spatial genomics: mapping human steatotic liver disease

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as non-alcoholic fatty liver disease) is a leading cause of chronic liver disease worldwide. MASLD can progress to metabolic dysfunction-associated steatohepatitis (MASH, formerly known as non-alcoholic steatohepatitis) with subsequent liver cirrhosis and hepatocellular carcinoma formation. The advent of current technologies such as single-cell and single-nuclei RNA sequencing have transformed our understanding of the liver in homeostasis and disease. The next frontier is contextualizing this single-cell information in its native spatial orientation. This understanding will markedly accelerate discovery science in hepatology, resulting in a further step-change in our knowledge of liver biology and pathobiology. In this Review, we discuss up-to-date knowledge of MASLD development and progression and how the burgeoning field of spatial genomics is driving exciting new developments in our understanding of human liver disease pathogenesis and therapeutic target identification.

Original languageEnglish
Pages (from-to)646-660
JournalNature Reviews Gastroenterology & Hepatology
Volume21
Issue number9
Early online date23 Apr 2024
DOIs
Publication statusPublished - Sept 2024

Keywords / Materials (for Non-textual outputs)

  • Disease Progression
  • Genomics
  • Humans
  • Liver Neoplasms/genetics
  • Non-alcoholic Fatty Liver Disease/genetics
  • Single-Cell Analysis

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