Abstract
Repeat sequence motifs as well as unique sequences between nucleotides -150 and -22 of the human cytomegalovirus immediate-early 1 gene interact in vitro with nuclear proteins. We show that a transcriptional element between nucleotides -91 and -65 stimulated promoter activity in vivo and in vitro by binding specific cellular transcription factors. Finally, a common sequence motif, (T)TGG/AC, present in 15 of the determined binding sites suggests a particular class of nuclear factors associated with the immediate-early 1 gene.
Original language | English |
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Pages (from-to) | 1076-9 |
Number of pages | 4 |
Journal | Journal of Virology |
Volume | 62 |
Issue number | 3 |
Publication status | Published - 1988 |
Keywords / Materials (for Non-textual outputs)
- Base Sequence
- Binding Sites
- Cytomegalovirus
- DNA, Viral
- Enhancer Elements, Genetic
- Gene Products, tat
- Genes, Regulator
- Genes, Viral
- HeLa Cells
- Humans
- Molecular Sequence Data
- Promoter Regions, Genetic
- Repetitive Sequences, Nucleic Acid
- Transcription Factors