Specific ion channels control sensory gain, sensitivity, and kinetics in a tonic thermonociceptor

Gabriella Saro, Andrei-Stefan Lia, Saurabh Thayliyal, Filipe Marques, Karl Emanuel Busch, Dominique A Glauser

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Pain sensation and aversive behaviors entail the activation of nociceptor neurons, whose function is largely conserved across animals. The functional heterogeneity of nociceptors and ethical concerns are challenges for their study in mammalian models. Here, we investigate the function of a single type of genetically identified C. elegans thermonociceptor named FLP. Using calcium imaging in vivo, we demonstrate that FLP encodes thermal information in a tonic and graded manner over a wide thermal range spanning from noxious cold to noxious heat (8°C–36°C). This tonic-signaling mode allows FLP to trigger sustained behavioral changes necessary for escape behavior. Furthermore, we identify specific transient receptor potential, voltage-gated calcium, and sodium “leak” channels controlling sensory gain, thermal sensitivity, and signal kinetics, respectively, and show that the ryanodine receptor is required for long-lasting activation. Our work elucidates the task distribution among specific ion channels to achieve remarkable sensory properties in a tonic thermonociceptor in vivo.
Original languageEnglish
Pages (from-to)397-408.e4
Number of pages16
JournalCell Reports
Volume30
Issue number2
Early online date14 Jan 2020
DOIs
Publication statusE-pub ahead of print - 14 Jan 2020

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