Specification of CNS macrophage subsets occurs postnatally in defined niches

Takahiro Masuda; Lukas Amann; Gianni Monaco; Roman Sankowski; Ori Staszewski; Martin Krueger; Francesca Del Gaudio; Liqun He; Neil Paterson; Elisa Nent; Francisco Fernández-klett; Ayato Yamasaki; Maximilian Frosch; Maximilian Fliegauf; Lance Fredrick Pahutan Bosch; Hatice Ulupinar; Nora Hagemeyer; Dietmar Schreiner; Cayce Dorrier; Makoto Tsuda; Claudia Grothe; Anne Joutel; Richard Daneman; Christer Betsholtz; Urban Lendahl; Klaus-peter Knobeloch; Tim Lämmermann; Josef Priller; Katrin Kierdorf; Marco Prinz

doi:10.1038/s41586-022-04596-2

Specification of CNS macrophage subsets occurs postnatally in defined niches

Takahiro Masuda, Lukas Amann, Gianni Monaco, Roman Sankowski, Ori Staszewski, Martin Krueger, Francesca Del Gaudio, Liqun He, Neil Paterson, Elisa Nent, Francisco Fernández-klett, Ayato Yamasaki, Maximilian Frosch, Maximilian Fliegauf, Lance Fredrick Pahutan Bosch, Hatice Ulupinar, Nora Hagemeyer, Dietmar Schreiner, Cayce Dorrier, Makoto TsudaClaudia Grothe, Anne Joutel, Richard Daneman, Christer Betsholtz, Urban Lendahl, Klaus-peter Knobeloch, Tim Lämmermann, Josef Priller, Katrin Kierdorf, Marco Prinz

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Original language	English
Pages (from-to)	740-748
Journal	Nature
Volume	604
Issue number	7907
DOIs	https://doi.org/10.1038/s41586-022-04596-2
Publication status	Published - 20 Apr 2022

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Author Correction: Specification of CNS macrophage subsets occurs postnatally in defined niches
Masuda, T., Amann, L., Monaco, G., Sankowski, R., Staszewski, O., Krueger, M., Del Gaudio, F., He, L., Paterson, N., Nent, E., Fernández-Klett, F., Yamasaki, A., Frosch, M., Fliegauf, M., Bosch, L. F. P., Ulupinar, H., Hagemeyer, N., Schreiner, D., Dorrier, C., Tsuda, M., & 10 othersGrothe, C., Joutel, A., Daneman, R., Betsholtz, C., Lendahl, U., Knobeloch, K-P., Lämmermann, T., Priller, J., Kierdorf, K. & Prinz, M., 21 Sept 2022, In: Nature. 610, p. E1
Research output: Contribution to journal › Article › peer-review

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Masuda, T., Amann, L., Monaco, G., Sankowski, R., Staszewski, O., Krueger, M., Del Gaudio, F., He, L., Paterson, N., Nent, E., Fernández-klett, F., Yamasaki, A., Frosch, M., Fliegauf, M., Bosch, L. F. P., Ulupinar, H., Hagemeyer, N., Schreiner, D., Dorrier, C., ... Prinz, M. (2022). Specification of CNS macrophage subsets occurs postnatally in defined niches. Nature, 604(7907), 740-748. https://doi.org/10.1038/s41586-022-04596-2

@article{86c131e15fa14bfc9e42bb4b7e68e912,

title = "Specification of CNS macrophage subsets occurs postnatally in defined niches",

author = "Takahiro Masuda and Lukas Amann and Gianni Monaco and Roman Sankowski and Ori Staszewski and Martin Krueger and {Del Gaudio}, Francesca and Liqun He and Neil Paterson and Elisa Nent and Francisco Fern{\'a}ndez-klett and Ayato Yamasaki and Maximilian Frosch and Maximilian Fliegauf and Bosch, {Lance Fredrick Pahutan} and Hatice Ulupinar and Nora Hagemeyer and Dietmar Schreiner and Cayce Dorrier and Makoto Tsuda and Claudia Grothe and Anne Joutel and Richard Daneman and Christer Betsholtz and Urban Lendahl and Klaus-peter Knobeloch and Tim L{\"a}mmermann and Josef Priller and Katrin Kierdorf and Marco Prinz",

note = "Funding Information: We thank E. Barleon and M. Fukuzaki for technical assistance and D. Gr{\"u}n and Sagar for their support with the preparation of the scRNA-seq data. We thank the Lighthouse Core Facility (LCF) for their support with cell sorting. LCF is funded in part by the Medical Faculty, University of Freiburg (Project numbers 2021/A2-Fol; 2021/B3-Fol) and the DFG (Project number 450392965). We are also grateful to R. F{\"a}ssler and D. Critchley for providing mouse strains. T.M. was supported by AMED (JP20gm6310016 (PRIME), JP21wm0425001), JSPS (KAKENHI JP20K22687, JP21H02752, JP21H00204), the Kanae Foundation, the Naito Foundation, the Inamori Foundation and the Takeda Science Foundation. M.P. was supported by the Sobek Foundation, the Ernst Jung Foundation, the Novo Nordisk Prize, the DFG SFB 992 (Project ID 192904750), SFB1160 (Project ID 256073931), Reinhart-Koselleck-Grant (Project ID 279642606) and Gottfried Wilhelm Leibniz Prize, the Alzheimer Forschung Initiative e.V. (AFI) and the Ministry of Science, Research and Arts, Baden-Wuerttemberg (Sonderlinie {\textquoteleft}Neuroinflammation{\textquoteright}). This study was supported by the DFG under Germany{\textquoteright}s Excellence Strategy (CIBSS – EXC-2189 – Project ID 390939984). J.P. was supported by the UK DRI Momentum and Programme Leader Awards and the DFG SFB/TRR265. K.K. was supported by the Fritz Thyssen Foundation, by the DFG project grant (Project ID 432207796). K.K. and M.P. were supported by the DFG project grants within the CRC1479 (Project ID 441891347). K.K., K.-P.K., J.P., E.N., T.L. and M.P. were supported by the DFG-funded CRC/TRR167 {\textquoteleft}NeuroMac{\textquoteright}, Project ID 259373024. K.-P.K. was supported by the DFG GRK 2606 (Project ID 423813989). C.B. and U.L. were supported by the Swedish Brain Foundation and Erling-Persson Foundation. N.P. was supported by the DFG-funded project ID 89986987 (SFB 850). Funding Information: We thank E. Barleon and M. Fukuzaki for technical assistance and D. Gr{\"u}n and Sagar for their support with the preparation of the scRNA-seq data. We thank the Lighthouse Core Facility (LCF) for their support with cell sorting. LCF is funded in part by the Medical Faculty, University of Freiburg (Project numbers 2021/A2-Fol; 2021/B3-Fol) and the DFG (Project number 450392965). We are also grateful to R. F{\"a}ssler and D. Critchley for providing mouse strains. T.M. was supported by AMED (JP20gm6310016 (PRIME), JP21wm0425001), JSPS (KAKENHI JP20K22687, JP21H02752, JP21H00204), the Kanae Foundation, the Naito Foundation, the Inamori Foundation and the Takeda Science Foundation. M.P. was supported by the Sobek Foundation, the Ernst Jung Foundation, the Novo Nordisk Prize, the DFG SFB 992 (Project ID 192904750), SFB1160 (Project ID 256073931), Reinhart-Koselleck-Grant (Project ID 279642606) and Gottfried Wilhelm Leibniz Prize, the Alzheimer Forschung Initiative e.V. (AFI) and the Ministry of Science, Research and Arts, Baden-Wuerttemberg (Sonderlinie {\textquoteleft}Neuroinflammation{\textquoteright}). This study was supported by the DFG under Germany{\textquoteright}s Excellence Strategy (CIBSS – EXC-2189 – Project ID 390939984). J.P. was supported by the UK DRI Momentum and Programme Leader Awards and the DFG SFB/TRR265. K.K. was supported by the Fritz Thyssen Foundation, by the DFG project grant (Project ID 432207796). K.K. and M.P. were supported by the DFG project grants within the CRC1479 (Project ID 441891347). K.K., K.-P.K., J.P., E.N., T.L. and M.P. were supported by the DFG-funded CRC/TRR167 {\textquoteleft}NeuroMac{\textquoteright}, Project ID 259373024. K.-P.K. was supported by the DFG GRK 2606 (Project ID 423813989). C.B. and U.L. were supported by the Swedish Brain Foundation and Erling-Persson Foundation. N.P. was supported by the DFG-funded project ID 89986987 (SFB 850). Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2022",

month = apr,

day = "20",

doi = "10.1038/s41586-022-04596-2",

language = "English",

volume = "604",

pages = "740--748",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

number = "7907",

}

Masuda, T, Amann, L, Monaco, G, Sankowski, R, Staszewski, O, Krueger, M, Del Gaudio, F, He, L, Paterson, N, Nent, E, Fernández-klett, F, Yamasaki, A, Frosch, M, Fliegauf, M, Bosch, LFP, Ulupinar, H, Hagemeyer, N, Schreiner, D, Dorrier, C, Tsuda, M, Grothe, C, Joutel, A, Daneman, R, Betsholtz, C, Lendahl, U, Knobeloch, K, Lämmermann, T, Priller, J, Kierdorf, K & Prinz, M 2022, 'Specification of CNS macrophage subsets occurs postnatally in defined niches', Nature, vol. 604, no. 7907, pp. 740-748. https://doi.org/10.1038/s41586-022-04596-2

TY - JOUR

T1 - Specification of CNS macrophage subsets occurs postnatally in defined niches

AU - Masuda, Takahiro

AU - Amann, Lukas

AU - Monaco, Gianni

AU - Sankowski, Roman

AU - Staszewski, Ori

AU - Krueger, Martin

AU - Del Gaudio, Francesca

AU - He, Liqun

AU - Paterson, Neil

AU - Nent, Elisa

AU - Fernández-klett, Francisco

AU - Yamasaki, Ayato

AU - Frosch, Maximilian

AU - Fliegauf, Maximilian

AU - Bosch, Lance Fredrick Pahutan

AU - Ulupinar, Hatice

AU - Hagemeyer, Nora

AU - Schreiner, Dietmar

AU - Dorrier, Cayce

AU - Tsuda, Makoto

AU - Grothe, Claudia

AU - Joutel, Anne

AU - Daneman, Richard

AU - Betsholtz, Christer

AU - Lendahl, Urban

AU - Knobeloch, Klaus-peter

AU - Lämmermann, Tim

AU - Priller, Josef

AU - Kierdorf, Katrin

AU - Prinz, Marco

N1 - Funding Information: We thank E. Barleon and M. Fukuzaki for technical assistance and D. Grün and Sagar for their support with the preparation of the scRNA-seq data. We thank the Lighthouse Core Facility (LCF) for their support with cell sorting. LCF is funded in part by the Medical Faculty, University of Freiburg (Project numbers 2021/A2-Fol; 2021/B3-Fol) and the DFG (Project number 450392965). We are also grateful to R. Fässler and D. Critchley for providing mouse strains. T.M. was supported by AMED (JP20gm6310016 (PRIME), JP21wm0425001), JSPS (KAKENHI JP20K22687, JP21H02752, JP21H00204), the Kanae Foundation, the Naito Foundation, the Inamori Foundation and the Takeda Science Foundation. M.P. was supported by the Sobek Foundation, the Ernst Jung Foundation, the Novo Nordisk Prize, the DFG SFB 992 (Project ID 192904750), SFB1160 (Project ID 256073931), Reinhart-Koselleck-Grant (Project ID 279642606) and Gottfried Wilhelm Leibniz Prize, the Alzheimer Forschung Initiative e.V. (AFI) and the Ministry of Science, Research and Arts, Baden-Wuerttemberg (Sonderlinie ‘Neuroinflammation’). This study was supported by the DFG under Germany’s Excellence Strategy (CIBSS – EXC-2189 – Project ID 390939984). J.P. was supported by the UK DRI Momentum and Programme Leader Awards and the DFG SFB/TRR265. K.K. was supported by the Fritz Thyssen Foundation, by the DFG project grant (Project ID 432207796). K.K. and M.P. were supported by the DFG project grants within the CRC1479 (Project ID 441891347). K.K., K.-P.K., J.P., E.N., T.L. and M.P. were supported by the DFG-funded CRC/TRR167 ‘NeuroMac’, Project ID 259373024. K.-P.K. was supported by the DFG GRK 2606 (Project ID 423813989). C.B. and U.L. were supported by the Swedish Brain Foundation and Erling-Persson Foundation. N.P. was supported by the DFG-funded project ID 89986987 (SFB 850). Funding Information: We thank E. Barleon and M. Fukuzaki for technical assistance and D. Grün and Sagar for their support with the preparation of the scRNA-seq data. We thank the Lighthouse Core Facility (LCF) for their support with cell sorting. LCF is funded in part by the Medical Faculty, University of Freiburg (Project numbers 2021/A2-Fol; 2021/B3-Fol) and the DFG (Project number 450392965). We are also grateful to R. Fässler and D. Critchley for providing mouse strains. T.M. was supported by AMED (JP20gm6310016 (PRIME), JP21wm0425001), JSPS (KAKENHI JP20K22687, JP21H02752, JP21H00204), the Kanae Foundation, the Naito Foundation, the Inamori Foundation and the Takeda Science Foundation. M.P. was supported by the Sobek Foundation, the Ernst Jung Foundation, the Novo Nordisk Prize, the DFG SFB 992 (Project ID 192904750), SFB1160 (Project ID 256073931), Reinhart-Koselleck-Grant (Project ID 279642606) and Gottfried Wilhelm Leibniz Prize, the Alzheimer Forschung Initiative e.V. (AFI) and the Ministry of Science, Research and Arts, Baden-Wuerttemberg (Sonderlinie ‘Neuroinflammation’). This study was supported by the DFG under Germany’s Excellence Strategy (CIBSS – EXC-2189 – Project ID 390939984). J.P. was supported by the UK DRI Momentum and Programme Leader Awards and the DFG SFB/TRR265. K.K. was supported by the Fritz Thyssen Foundation, by the DFG project grant (Project ID 432207796). K.K. and M.P. were supported by the DFG project grants within the CRC1479 (Project ID 441891347). K.K., K.-P.K., J.P., E.N., T.L. and M.P. were supported by the DFG-funded CRC/TRR167 ‘NeuroMac’, Project ID 259373024. K.-P.K. was supported by the DFG GRK 2606 (Project ID 423813989). C.B. and U.L. were supported by the Swedish Brain Foundation and Erling-Persson Foundation. N.P. was supported by the DFG-funded project ID 89986987 (SFB 850). Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature Limited.

PY - 2022/4/20

Y1 - 2022/4/20

U2 - 10.1038/s41586-022-04596-2

DO - 10.1038/s41586-022-04596-2

M3 - Article

SN - 0028-0836

VL - 604

SP - 740

EP - 748

JO - Nature

JF - Nature

IS - 7907

ER -

Specification of CNS macrophage subsets occurs postnatally in defined niches

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Research output

Author Correction: Specification of CNS macrophage subsets occurs postnatally in defined niches

Cite this