Specificity of the immune response of mice to herpes simplex virus glycoproteins B and D constitutively expressed on L cell lines

Barbara A. Blacklaws, Anthony Nash, G Darby

Research output: Contribution to journalArticlepeer-review

Abstract

Mouse L cell lines have been developed which constitutively express glycoproteins B (gB) and D (gD) of herpes simplex virus type 1. When used to study the immune response of mice to the viral glycoproteins, it was found that both gB and gD induce a delayed type hypersensitivity response and both also induce an antibody response, but only the cell line expressing gD could stimulate the production of neutralizing antibody. Virus-specific cytotoxic T lymphocytes (CTLs) recognized gB expressed by the cell line and this line could also induce CTLs in mice. Recognition of gD by major histocompatibility complex class I restricted CTLs was never seen. Vaccination of mice with the cell lines provided protection from viral challenge and inhibited the establishment of a latent infection, although gD proved to be the better protective immunogen.
Original languageEnglish
Pages (from-to)1103-14
Number of pages12
JournalJournal of General Virology
Volume68
Issue number4
DOIs
Publication statusPublished - Apr 1987

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