Spices to Control COVID-19 Symptoms: Yes, but Not Only…

Jean Bousquet, Wienczyslawa Czarlewski, Torsten Zuberbier, Joaquim Mullol, Hubert Blain, Jean-Paul Cristol, Rafael De La Torre, Vincent Le Moing, Nieves Pizarro Lozano, Anna Bedbrook, Ioana Agache, Cezmi A Akdis, G Walter Canonica, Alvaro A Cruz, Alessandro Fiocchi, Joao A Fonseca, Susana Fonseca, Bilun Gemicioğlu, Tari Haahtela, Guido IaccarinoJuan Carlos Ivancevich, Marek Jutel, Ludger Klimek, Piotr Kuna, Désirée E Larenas-Linnemann, Erik Melén, Yoshitaka Okamoto, Nikolaos G Papadopoulos, Oliver Pfaar, Jacques Reynes, Yves Rolland, Philip W Rouadi, Boleslaw Samolinski, Aziz Sheikh, Sanna Toppila-Salmi, Arunas Valiulis, Hak-Jong Choi, Hyun Ju Kim, Josep M Anto

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

There are large country variations in COVID-19 death rates that may be partly explained by diet. Many countries with low COVID-19 death rates have a common feature of eating large quantities of fermented vegetables such as cabbage and, in some continents, various spices. Fermented vegetables and spices are agonists of the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and spices are transient receptor potential ankyrin 1 and vanillin 1 (TRPA1/V1) agonists. These mechanisms may explain many COVID-19 symptoms and severity. It appears that there is a synergy between Nrf2 and TRPA1/V1 foods that may explain the role of diet in COVID-19. One of the mechanisms of COVID-19 appears to be an oxygen species (ROS)-mediated process in synergy with TRP channels, modulated by Nrf2 pathways. Spicy foods are likely to desensitize TRP channels and act in synergy with exogenous antioxidants that activate the Nrf2 pathway.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalInternational archives of allergy and immunology
Early online date22 Dec 2020
Publication statusE-pub ahead of print - 22 Dec 2020


Dive into the research topics of 'Spices to Control COVID-19 Symptoms: Yes, but Not Only…'. Together they form a unique fingerprint.

Cite this