Spindle checkpoint silencing: ensuring rapid and concerted anaphase onset

Kevin G Hardwick, Jagesh V Shah

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The spindle checkpoint delays anaphase onset in the presence of defective kinetochore-microtubule attachments. Such delays can last for just a few minutes or several hours, but very shortly after all chromosomes achieve bi-orientation, a remarkably synchronous anaphase ensues. We are beginning to understand the pathways involved in silencing spindle checkpoint signals and subsequent activation of the anaphase-promoting complex. Here, we review recent advances made in our understanding of the molecular mechanisms regulating this critical cell cycle transition.
Original languageEnglish
Pages (from-to)55
JournalF1000 biology reports
Publication statusPublished - 2010


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