SPONTANEOUS DEVELOPMENT OF MALIGNANT PHASE HYPERTENSION IN TRANSGENIC REN-2 RATS

C E WHITWORTH, S FLEMING, A D CUMMING, J J MORTON, N J T BURNS, B C WILLIAMS, John Mullins

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats. Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid necrosis of renal afferent arterioles, renal failure and evidence of renin-angiotensin system activation. It appears that introduction of an additional genetic factor or factors into a monogenic model of hypertension results in malignant phase hypertension.

Original languageEnglish
Pages (from-to)1528-1532
Number of pages5
JournalKidney International
Volume46
Issue number6
Publication statusPublished - Dec 1994

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