Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study

Co-Operative Study on Brain Injury Depolarisations, Jed A Hartings, M Ross Bullock, David O Okonkwo, Lilian S Murray, Gordon D Murray, Martin Fabricius, Andrew Ir Maas, Johannes Woitzik, Oliver Sakowitz, Bruce Mathern, Bob Roozenbeek, Hester Lingsma, Jens P Dreier, Ava M Puccio, Lori A Shutter, Clemens Pahl, Anthony J Strong

Research output: Contribution to journalArticlepeer-review

Abstract

Pathological waves of spreading mass neuronal depolarisation arise repeatedly in injured, but potentially salvageable, grey matter in 50-60% of patients after traumatic brain injury (TBI). We aimed to ascertain whether spreading depolarisations are independently associated with unfavourable neurological outcome.
Original languageEnglish
Pages (from-to)1058-64
Number of pages7
JournalLancet Neurology
Volume10
Issue number12
DOIs
Publication statusPublished - 2011

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