Sputum trace metals are biomarkers of inflammatory and suppurative lung disease

R. D. Gray, A. Duncan, D. Noble, M. Imrie, D. S. O'Reilly, J. A. Innes, D. J. Porteous, A. P. Greening, A. C. Boyd

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Induced sputum cytology and protein biomarkers can be used to assess airways inflammation. Increases in sputum iron have been described in inflammatory lung disease. We hypothesized that other sputum metals may be affected by airways inflammation and investigated their potential value as biomarkers. METHODS: Sputum was obtained from 20 healthy control subjects and from patients with inflammatory pulmonary diseases (23 with cystic fibrosis [CF], 16 with bronchiectasis, 17 with asthma, and 23 with COPD), and iron, zinc, manganese, and copper were measured. Fourteen patients with CF were also studied through an exacerbation cycle. RESULTS: Sputum zinc and iron were elevated in CF and non-CF bronchiectasis vs controls (P <.001, zinc; P <.01 iron). Manganese was elevated in asthma (P <.01) and bronchiectasis (P <.05) vs controls. Copper was elevated in CF vs controls (P <.05). Zinc decreased (P <.01) following treatment of CF exacerbation. In subjects with CF zinc levels correlated with other biomarkers. CONCLUSIONS: These results suggest a relationship of high concentrations of total zinc and iron with airways inflammation in CF and non-CF bronchiectasis, with longitudinal changes being observed in CF. Further work is required to elucidate potential inflammatory mechanisms related to these observations.
Original languageEnglish
Pages (from-to)635-641
Number of pages7
JournalChest
Volume137
Issue number3
DOIs
Publication statusPublished - 2010

Keywords

  • Adult Aged Asthma/*diagnosis/metabolism Biological Markers/*analysis Bronchiectasis/*diagnosis/metabolism Copper/analysis Cystic Fibrosis/*diagnosis/metabolism Diagnosis, Differential Female Humans Iron/analysis Male Manganese/analysis Middle Aged Pulmonary Disease, Chronic Obstructive/*diagnosis/metabolism Reproducibility of Results Spectrum Analysis Sputum/*chemistry Suppuration Trace Elements/*analysis Zinc/analysis

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