Squamous carcinoma of the uterine cervix with CIN 3-like growth pattern: An under-diagnosed lesion

A. I. Al-Nafussi, Hannah Monaghan

Research output: Contribution to journalArticlepeer-review

Abstract

Invasive squamous carcinomas of the cervix have traditionally been classified into keratinizing, non-keratinizing, verrucous, warty (condylomatous), papillary transitional (squamo-transitional), and lymphoepithelioma-like carcinomas. The majority of these tumors are easily recognized. We present for the first time the pathological appearances of six cases of invasive squamous carcinoma with growth pattern simulating tangentially cut CIN 3 involving endocervical glandular crypts/clefts. In all cases initial diagnosis on biopsy and/or loop excision was thought to be CIN 3, perhaps with suspicion of early invasion. On further excision and/or on clinical grounds the tumors were frankly invasive. We propose the use of the term squamous carcinoma with "CIN 3-like growth pattern" for such lesions. This is in order to avoid misinterpretation as CIN 3 with subsequent inappropriate management of patients with this type of tumor.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalInternational Journal of Gynecological Cancer
Volume10
Issue number2
Publication statusPublished - Mar 2000

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