Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition

Egle Avizienyte, Margaret C Frame

Research output: Contribution to journalArticlepeer-review

Abstract

Src kinase controls cellular adhesions, including cadherin-based intercellular adhesions and integrin-mediated cell-matrix adhesions. In epithelial cells, Src activation, or increased signalling from migratory growth factor receptors via Src, induces an adhesion switch that enhances dynamic cell-matrix adhesions and migratory capacity while suppressing intercellular contact. Moreover, Src and the associated tyrosine kinase FAK are at the heart of the recently identified crosstalk between integrin- and cadherin-mediated adhesions of epithelial cells, particularly during the epithelial-to-mesenchymal transition.
Original languageEnglish
Pages (from-to)542-7
Number of pages6
JournalCurrent opinion in cell biology
Volume17
Issue number5
DOIs
Publication statusPublished - Oct 2005

Keywords

  • Animals
  • Cadherins
  • Cell Adhesion
  • Cell Differentiation
  • Endocytosis
  • Epithelial Cells
  • Humans
  • Integrins
  • Mesoderm
  • Models, Biological
  • Neoplasms
  • Signal Transduction
  • src-Family Kinases

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