TY - JOUR
T1 - Src and focal adhesion kinase as therapeutic targets in cancer
AU - Brunton, Valerie G
AU - Frame, Margaret C
PY - 2008/8
Y1 - 2008/8
N2 - Over the past few years small molecule inhibitors of both Src family kinases and focal adhesion kinase (FAK) have entered clinical studies for the treatment of solid tumours. These adhesion-linked kinases are involved in a number of pathways that have impact on the behaviour of tumour cells and the challenge is now, how to take these forward in the clinical setting.
AB - Over the past few years small molecule inhibitors of both Src family kinases and focal adhesion kinase (FAK) have entered clinical studies for the treatment of solid tumours. These adhesion-linked kinases are involved in a number of pathways that have impact on the behaviour of tumour cells and the challenge is now, how to take these forward in the clinical setting.
UR - http://www.scopus.com/inward/record.url?scp=51449088226&partnerID=8YFLogxK
U2 - 10.1016/j.coph.2008.06.012
DO - 10.1016/j.coph.2008.06.012
M3 - Literature review
C2 - 18625340
SN - 1471-4892
VL - 8
SP - 427
EP - 432
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
IS - 4
ER -