SRC family kinase activity is up-regulated in hormone-refractory prostate cancer

Oleg Tatarov; Thomas J Mitchell; Morag Seywright; Hing Y Leung; Valerie G Brunton; Joanne Edwards

doi:10.1158/1078-0432.CCR-08-1857

SRC family kinase activity is up-regulated in hormone-refractory prostate cancer

Oleg Tatarov, Thomas J Mitchell, Morag Seywright, Hing Y Leung, Valerie G Brunton, Joanne Edwards

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Although Src family kinase (SFK) inhibitors are now in clinical trials for the treatment of androgen-independent prostate cancer (AIPC), there are no studies relating SFK activation to patient survival. This study was designed to determine if SFK activation was up-regulated with the development of AIPC and if patients could be selected who were more likely to respond to therapy.

Original language	English
Pages (from-to)	3540-9
Number of pages	10
Journal	Clinical Cancer Research
Volume	15
Issue number	10
DOIs	https://doi.org/10.1158/1078-0432.CCR-08-1857
Publication status	Published - 2009

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10.1158/1078-0432.CCR-08-1857

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title = "SRC family kinase activity is up-regulated in hormone-refractory prostate cancer",

abstract = "Although Src family kinase (SFK) inhibitors are now in clinical trials for the treatment of androgen-independent prostate cancer (AIPC), there are no studies relating SFK activation to patient survival. This study was designed to determine if SFK activation was up-regulated with the development of AIPC and if patients could be selected who were more likely to respond to therapy.",

author = "Oleg Tatarov and Mitchell, {Thomas J} and Morag Seywright and Leung, {Hing Y} and Brunton, {Valerie G} and Joanne Edwards",

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T1 - SRC family kinase activity is up-regulated in hormone-refractory prostate cancer

AU - Tatarov, Oleg

AU - Mitchell, Thomas J

AU - Seywright, Morag

AU - Leung, Hing Y

AU - Brunton, Valerie G

AU - Edwards, Joanne

PY - 2009

Y1 - 2009

N2 - Although Src family kinase (SFK) inhibitors are now in clinical trials for the treatment of androgen-independent prostate cancer (AIPC), there are no studies relating SFK activation to patient survival. This study was designed to determine if SFK activation was up-regulated with the development of AIPC and if patients could be selected who were more likely to respond to therapy.

AB - Although Src family kinase (SFK) inhibitors are now in clinical trials for the treatment of androgen-independent prostate cancer (AIPC), there are no studies relating SFK activation to patient survival. This study was designed to determine if SFK activation was up-regulated with the development of AIPC and if patients could be selected who were more likely to respond to therapy.

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U2 - 10.1158/1078-0432.CCR-08-1857

DO - 10.1158/1078-0432.CCR-08-1857

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C2 - 19447874

SN - 1078-0432

VL - 15

SP - 3540

EP - 3549

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 10

ER -

SRC family kinase activity is up-regulated in hormone-refractory prostate cancer

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