Standardized evaluation of algorithms for computer-aided diagnosis of dementia based on structural MRI: the CADDementia challenge

Esther E Bron, Marion Smits, Wiesje M van der Flier, Hugo Vrenken, Frederik Barkhof, Philip Scheltens, Janne M Papma, Rebecca M E Steketee, Carolina Méndez Orellana, Rozanna Meijboom, Madalena Pinto, Joana R Meireles, Carolina Garrett, António J Bastos-Leite, Ahmed Abdulkadir, Olaf Ronneberger, Nicola Amoroso, Roberto Bellotti, David Cárdenas-Peña, Andrés M Álvarez-MezaChester V Dolph, Khan M Iftekharuddin, Simon F Eskildsen, Pierrick Coupé, Vladimir S Fonov, Katja Franke, Christian Gaser, Christian Ledig, Ricardo Guerrero, Tong Tong, Katherine R Gray, Elaheh Moradi, Jussi Tohka, Alexandre Routier, Stanley Durrleman, Alessia Sarica, Giuseppe Di Fatta, Francesco Sensi, Andrea Chincarini, Garry M Smith, Zhivko V Stoyanov, Lauge Sørensen, Mads Nielsen, Sabina Tangaro, Paolo Inglese, Christian Wachinger, Martin Reuter, John C van Swieten, Wiro J. Niessen, Stefan Klein

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Algorithms for computer-aided diagnosis of dementia based on structural MRI have demonstrated high performance in the literature, but are difficult to compare as different data sets and methodology were used for evaluation. In addition, it is unclear how the algorithms would perform on previously unseen data, and thus, how they would perform in clinical practice when there is no real opportunity to adapt the algorithm to the data at hand. To address these comparability, generalizability and clinical applicability issues, we organized a grand challenge that aimed to objectively compare algorithms based on a clinically representative multi-center data set. Using clinical practice as the starting point, the goal was to reproduce the clinical diagnosis. Therefore, we evaluated algorithms for multi-class classification of three diagnostic groups: patients with probable Alzheimer's disease, patients with mild cognitive impairment and healthy controls. The diagnosis based on clinical criteria was used as reference standard, as it was the best available reference despite its known limitations. For evaluation, a previously unseen test set was used consisting of 354 T1-weighted MRI scans with the diagnoses blinded. Fifteen research teams participated with a total of 29 algorithms. The algorithms were trained on a small training set (n=30) and optionally on data from other sources (e.g., the Alzheimer's Disease Neuroimaging Initiative, the Australian Imaging Biomarkers and Lifestyle flagship study of aging). The best performing algorithm yielded an accuracy of 63.0% and an area under the receiver-operating-characteristic curve (AUC) of 78.8%. In general, the best performances were achieved using feature extraction based on voxel-based morphometry or a combination of features that included volume, cortical thickness, shape and intensity. The challenge is open for new submissions via the web-based framework: http://caddementia.grand-challenge.org.

Original languageEnglish
Pages (from-to)562-579
Number of pages18
JournalNeuroImage
Volume111
DOIs
Publication statusPublished - 2015

Keywords / Materials (for Non-textual outputs)

  • Aged
  • Algorithms
  • Alzheimer Disease
  • Cognitive Dysfunction
  • Diagnosis, Computer-Assisted
  • Humans
  • Image Interpretation, Computer-Assisted
  • Magnetic Resonance Imaging
  • Middle Aged
  • Sensitivity and Specificity
  • Comparative Study
  • Evaluation Studies
  • Journal Article
  • Multicenter Study

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