Static response of coated microbubbles: Modeling simulations and parameter estimation

Alkmini Lytra, Nikos Pelekasis*, Vassilis Sboros, Emmanouil Glynos, Vasileios Koutsos

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The mechanical response of contrast agent microbubbles subject to a static load was investigated in force-deformation curves. Asymptotic relations are fitted with experimental AFM measurements of polymeric microbubbles available in the literature. The elastic modulus and shell thickness are estimated based on the transition from the classical linear (Reissner) to the nonlinear (Pogorelov) regime. The estimated value of the elastic modulus is in the order of GPa and the shell thickness in the order of nm, in good agreement with independent estimates. Numerical simulations recover the above transition and identify a third regime, dominated by the compressibility of the enclosed gas.

Original languageEnglish
Title of host publicationProcedia IUTAM
PublisherElsevier
Pages123-133
Number of pages11
Volume16
DOIs
Publication statusPublished - 2015
EventIUTAM Symposium on Dynamics of Capsules, Vesicles and Cells in Flow, DynaCaps 2014 - Compiegne, France
Duration: 15 Jul 201419 Jul 2014

Conference

ConferenceIUTAM Symposium on Dynamics of Capsules, Vesicles and Cells in Flow, DynaCaps 2014
CountryFrance
CityCompiegne
Period15/07/1419/07/14

Keywords

  • area dilatation
  • bending
  • bending modulus
  • gas compressibillity
  • shell thickness
  • stretching

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