Statins in community acquired pneumonia: Evidence from experimental and clinical studies

James D. Chalmers, Philip M. Short, Pallavi Mandal, Ahsan Akram, Adam T. Hill

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

Statins are widely used to lower cholesterol and prevent complications of cardiovascular disease. The non-lipid lowering (pleiotropic) effects of statins may also have applications to the management of infections. These include effects on endothelial function, inflammation and coagulation pathways. Several observational studies have shown a significant reduction in 30-day mortality associated with prior statin therapy in hospitalised patients with sepsis and community acquired pneumonia.

This article explores the evidence for statins as novel therapy in community acquired pneumonia. Experimental and animal studies suggest statins attenuate acute lung injury by modulating neutrophil function, reducing pro-inflammatory cytokine release and reducing vascular leak. Statins reduce endothelial dysfunction and have anti-thrombotic effects that improve outcome from pneumonia and sepsis in animal models. Clinical studies have provided conflicting results, but many suggest that statins may have a role in preventing pneumonia, or improving prognosis in hospitalised patients with community-acquired pneumonia. (C) 2010 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)1081-1091
Number of pages11
JournalRespiratory Medicine
Volume104
Issue number8
DOIs
Publication statusPublished - Aug 2010

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