Statistical mapping of the effect of knee extension on thigh muscle viscoelastic properties using magnetic resonance elastography

Eric Barnhill, Paul Kennedy, Steven Hammer, Edwin J R van Beek, Colin Brown, Neil Roberts

Research output: Contribution to journalArticlepeer-review

Abstract

Skeletal muscle viscoelastic properties reflect muscle microstructure and neuromuscular activation. Elastographic methods, including magnetic resonance elastography, have been used to characterize muscle viscoelastic properties in terms of region of interest (ROI) measurements. The present study extended this approach to create thresholded pixel-by-pixel maps of viscoelastic properties of skeletal muscle during rest and knee extension in eleven subjects. ROI measurements were taken for individual quadricep muscles and the quadriceps region as a whole, and the viscoelastic parameter map pixels were statistically tested at positive false discovery rate q ⩽ 0.25. ROI measurements showed significant (p ⩽ 0.05) increase in storage modulus (G') and loss modulus (G″), with G″ increasing more than G', in agreement with previous findings. The q-value maps further identified the vastus intermedius as the primary driver of this change, with greater G″/G' increase than surrounding regions. Additionally, a cluster of significant decrease in G″/G' was found in the region of vastus lateralis below the fulcrum point of the lift. Viscoelastic parameter mapping of contracted muscle allows new insight into the relationship between physiology, neuromuscular activation, and human performance.
Original languageEnglish
Pages (from-to)1675-98
Number of pages24
JournalPhysiological Measurement
Volume34
Issue number12
DOIs
Publication statusPublished - Dec 2013

Fingerprint Dive into the research topics of 'Statistical mapping of the effect of knee extension on thigh muscle viscoelastic properties using magnetic resonance elastography'. Together they form a unique fingerprint.

Cite this