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Abstract / Description of output
Fluctuations in the number of nascent RNA accurately reflect transcriptional activity. However,mathematical models predicting their distributions are difficult to solve analytically due to theirnon-Markovian nature stemming from transcriptional elongation. Here we circumvent this problemby deriving an exact relationship between the steady-state distribution of nascent RNA and the distributionof initiation times, which can be computed for any general initiation mechanism describedby a set of first-order reactions. We test our theory using simulations and live cell imaging data.
|Number of pages||14|
|Journal||Physical Review Research|
|Early online date||31 Jan 2023|
|Publication status||Published - 31 Jan 2023|
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1/04/21 → 31/03/24