Steady-state distributions of nascent RNA for general initiation mechanisms

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Abstract / Description of output

Fluctuations in the number of nascent RNA accurately reflect transcriptional activity. However,mathematical models predicting their distributions are difficult to solve analytically due to theirnon-Markovian nature stemming from transcriptional elongation. Here we circumvent this problemby deriving an exact relationship between the steady-state distribution of nascent RNA and the distributionof initiation times, which can be computed for any general initiation mechanism describedby a set of first-order reactions. We test our theory using simulations and live cell imaging data.
Original languageEnglish
Article number013064
Number of pages14
JournalPhysical Review Research
Issue number1
Early online date31 Jan 2023
Publication statusPublished - 31 Jan 2023


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