Steady state running rate sets the speed and accuracy of accumulation of swimming bacteria

Margaritis Voliotis, Jerko Rosko, Teuta Pilizota, Tanniemola B Liverpool

Research output: Contribution to journalArticlepeer-review

Abstract

We study the chemotaxis of a population of genetically identical swimming bacteria undergoing run and tumble dynamics driven by stochastic switching between clockwise and counterclockwise rotation of the flagellar rotary system, where the steady-state rate of the switching changes in different environments. Understanding chemotaxis quantitatively requires that one links the measured steady-state switching rates of the rotary system, as well as the directional changes of individual swimming bacteria in a gradient of chemoattractant/repellant, to the efficiency of a population of bacteria in moving up/down the gradient. Here we achieve this by using a probabilistic model, parametrized with our experimental data, and show that the response of a population to the gradient is complex. We find the changes to the steady-state switching rate in the absence of gradients affect the average speed of the swimming bacterial population response as well as the width of the distribution. Both must be taken into account when optimizing the overall response of the population in complex environments.

Original languageEnglish
Pages (from-to)3435–3444
Number of pages10
JournalBiophysical Journal
Volume121
Issue number18
Early online date30 Aug 2022
DOIs
Publication statusPublished - 20 Sep 2022

Fingerprint

Dive into the research topics of 'Steady state running rate sets the speed and accuracy of accumulation of swimming bacteria'. Together they form a unique fingerprint.

Cite this