Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation

Vilma Dembitz; Hannah Lawson; Richard Burt; Sirisha Natani; Céline Philippe; Sophie C. James; Samantha Atkinson; Jozef Durko; Lydia M. Wang; Joana Campos; Aoife M. S. Magee; Keith Woodley; Michael J. Austin; Ana Rio-Machin; Pedro Casado; Findlay Bewicke-Copley; Giovanny Rodriguez Blanco; Diego Pereira-Martins; Lieve Oudejans; Emeline Boet; Alex Von Kriegsheim; Juerg Schwaller; Andrew J. Finch; Bela Patel; Jean-Emmanuel Sarry; Jerome Tamburini; Jan jacob Schuringa; Lori Hazlehurst; John A. Copland III; Mariia Yuneva; Barrie Peck; Pedro Cutillas; Jude Fitzgibbon; Kevin Rouault-Pierre; Kamil Kranc; Paolo Gallipoli

doi:10.1038/s41375-024-02390-9

Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation

Vilma Dembitz, Hannah Lawson, Richard Burt, Sirisha Natani, Céline Philippe, Sophie C. James, Samantha Atkinson, Jozef Durko, Lydia M. Wang, Joana Campos, Aoife M. S. Magee, Keith Woodley, Michael J. Austin, Ana Rio-Machin, Pedro Casado, Findlay Bewicke-Copley, Giovanny Rodriguez Blanco, Diego Pereira-Martins, Lieve Oudejans, Emeline BoetAlex Von Kriegsheim, Juerg Schwaller, Andrew J. Finch, Bela Patel, Jean-Emmanuel Sarry, Jerome Tamburini, Jan jacob Schuringa, Lori Hazlehurst, John A. Copland III, Mariia Yuneva, Barrie Peck, Pedro Cutillas, Jude Fitzgibbon, Kevin Rouault-Pierre, Kamil Kranc, Paolo Gallipoli^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Leukemia
Early online date	26 Aug 2024
DOIs	https://doi.org/10.1038/s41375-024-02390-9
Publication status	E-pub ahead of print - 26 Aug 2024

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Dembitz, V., Lawson, H., Burt, R., Natani, S., Philippe, C., James, S. C., Atkinson, S., Durko, J., Wang, L. M., Campos, J., Magee, A. M. S., Woodley, K., Austin, M. J., Rio-Machin, A., Casado, P., Bewicke-Copley, F., Rodriguez Blanco, G., Pereira-Martins, D., Oudejans, L., ... Gallipoli, P. (2024). Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation. Leukemia. Advance online publication. https://doi.org/10.1038/s41375-024-02390-9

@article{ea88d9317c20446f86e38d7ee54c6882,

title = "Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation",

author = "Vilma Dembitz and Hannah Lawson and Richard Burt and Sirisha Natani and C{\'e}line Philippe and James, {Sophie C.} and Samantha Atkinson and Jozef Durko and Wang, {Lydia M.} and Joana Campos and Magee, {Aoife M. S.} and Keith Woodley and Austin, {Michael J.} and Ana Rio-Machin and Pedro Casado and Findlay Bewicke-Copley and {Rodriguez Blanco}, Giovanny and Diego Pereira-Martins and Lieve Oudejans and Emeline Boet and {Von Kriegsheim}, Alex and Juerg Schwaller and Finch, {Andrew J.} and Bela Patel and Jean-Emmanuel Sarry and Jerome Tamburini and Schuringa, {Jan jacob} and Lori Hazlehurst and {Copland III}, {John A.} and Mariia Yuneva and Barrie Peck and Pedro Cutillas and Jude Fitzgibbon and Kevin Rouault-Pierre and Kamil Kranc and Paolo Gallipoli",

year = "2024",

month = aug,

day = "26",

doi = "10.1038/s41375-024-02390-9",

language = "English",

journal = "Leukemia",

issn = "1476-5551",

publisher = "Nature Publishing Group",

}

Dembitz, V, Lawson, H, Burt, R, Natani, S, Philippe, C, James, SC, Atkinson, S, Durko, J, Wang, LM, Campos, J, Magee, AMS, Woodley, K, Austin, MJ, Rio-Machin, A, Casado, P, Bewicke-Copley, F, Rodriguez Blanco, G, Pereira-Martins, D, Oudejans, L, Boet, E, Von Kriegsheim, A, Schwaller, J, Finch, AJ, Patel, B, Sarry, J-E, Tamburini, J, Schuringa, JJ, Hazlehurst, L, Copland III, JA, Yuneva, M, Peck, B, Cutillas, P, Fitzgibbon, J, Rouault-Pierre, K, Kranc, K & Gallipoli, P 2024, 'Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation', Leukemia. https://doi.org/10.1038/s41375-024-02390-9

TY - JOUR

T1 - Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation

AU - Dembitz, Vilma

AU - Lawson, Hannah

AU - Burt, Richard

AU - Natani, Sirisha

AU - Philippe, Céline

AU - James, Sophie C.

AU - Atkinson, Samantha

AU - Durko, Jozef

AU - Wang, Lydia M.

AU - Campos, Joana

AU - Magee, Aoife M. S.

AU - Woodley, Keith

AU - Austin, Michael J.

AU - Rio-Machin, Ana

AU - Casado, Pedro

AU - Bewicke-Copley, Findlay

AU - Rodriguez Blanco, Giovanny

AU - Pereira-Martins, Diego

AU - Oudejans, Lieve

AU - Boet, Emeline

AU - Von Kriegsheim, Alex

AU - Schwaller, Juerg

AU - Finch, Andrew J.

AU - Patel, Bela

AU - Sarry, Jean-Emmanuel

AU - Tamburini, Jerome

AU - Schuringa, Jan jacob

AU - Hazlehurst, Lori

AU - Copland III, John A.

AU - Yuneva, Mariia

AU - Peck, Barrie

AU - Cutillas, Pedro

AU - Fitzgibbon, Jude

AU - Rouault-Pierre, Kevin

AU - Kranc, Kamil

AU - Gallipoli, Paolo

PY - 2024/8/26

Y1 - 2024/8/26

U2 - 10.1038/s41375-024-02390-9

DO - 10.1038/s41375-024-02390-9

M3 - Article

SN - 1476-5551

JO - Leukemia

JF - Leukemia

ER -