Stem cell-based therapies in ischemic heart diseases: a focus on aspects of microcirculation and inflammation

Junxi Wu, Jun Li, Nannan Zhang, Cuihua Zhang*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

Stem cells possessing the potential to replace damaged myocardium with functional myocytes have drawn increasing attention in the past decade in treating ischemic heart diseases; these diseases are the leading cause of morbidity and mortality in the world. The adult heart has recently been shown to contain a few cardiac stem cells (CSCs) that, in theory, suggest cardiac repair following acute myocardial infarction is possible if the CSC titer could be increased. Stem cell-based therapies, including hematopoietic stem cells and mesenchymal stem cells, were proven to be marginal and transitional. Multiple factors and mechanisms, rather than direct cardiac regeneration are involved in stem cell-mediated cardiac functional improvement. This review will focus on (1) the interaction between inflammation and stem cells; (2) the fate of stem cells at the microcirculatory level, and their subsequent influences on stem cell-based therapies.

Original languageEnglish
Pages (from-to)317-324
Number of pages8
JournalBasic research in cardiology
Volume106
Issue number3
DOIs
Publication statusPublished - May 2011

Keywords / Materials (for Non-textual outputs)

  • Stem cell
  • Inflammation
  • Microcirculation
  • Ischemic heart disease
  • Cardiac repair
  • Cell-based therapy
  • ACUTE MYOCARDIAL-INFARCTION
  • ENDOTHELIAL PROGENITOR CELLS
  • MEDIATED CARDIAC PROTECTION
  • MESENCHYMAL STROMAL CELLS
  • NECROSIS-FACTOR-ALPHA
  • TNF-ALPHA
  • REPERFUSION INJURY
  • RECEPTOR EXPRESSION
  • PROSTAGLANDIN E-2
  • PERIPHERAL-BLOOD

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