Stem cell differentiation and human liver disease

Wen-Li Zhou; Claire N. Medine; Liang Zhu; David C. Hay

doi:10.3748/wjg.v18.i17.2018

Stem cell differentiation and human liver disease

Wen-Li Zhou, Claire N. Medine, Liang Zhu, David C. Hay^*

^*Corresponding author for this work

Research output: Contribution to journal › Literature review › peer-review

Abstract

Human stem cells are scalable cell populations capable of cellular differentiation. This makes them a very attractive in vitro cellular resource and in theory provides unlimited amounts of primary cells. Such an approach has the potential to improve our understanding of human biology and treating disease. In the future it may be possible to deploy novel stem cell-based approaches to treat human liver diseases. In recent years, efficient hepatic differentiation from human stem cells has been achieved by several research groups including our own. In this review we provide an overview of the field and discuss the future potential and limitations of stem cell technology. (C) 2012 Baishideng. All rights reserved.

Original language	English
Pages (from-to)	2018-2025
Number of pages	8
Journal	World Journal of Gastroenterology
Volume	18
Issue number	17
DOIs	https://doi.org/10.3748/wjg.v18.i17.2018
Publication status	Published - 7 May 2012

Keywords

Transplantation
GENE-EXPRESSION
Regenerative medicine
PROGENITOR CELLS
EFFICIENT DIFFERENTIATION
DEFINED FACTORS
MARROW STROMAL CELLS
HEPATIC OVAL CELLS
Differentiation
Liver development
Pluripotent stem cells
IN-VITRO
Polymer chemistry
HUMAN BLASTOCYSTS
HEPATOCYTE-LIKE CELLS
FUNCTIONAL HEPATOCYTES
Hepatocyte-like cells
Bio-artificial liver

Access to Document

10.3748/wjg.v18.i17.2018

Stem cell differentiation and human liver diseaseFinal published version, 872 KBLicence: Creative Commons: Attribution Non-Commercial (CC-BY-NC)

http://www.wjgnet.com/1007-9327/full/v18/i17/2018.htm

Cite this

@article{92f638542f8644b4983382679bb31095,

title = "Stem cell differentiation and human liver disease",

abstract = "Human stem cells are scalable cell populations capable of cellular differentiation. This makes them a very attractive in vitro cellular resource and in theory provides unlimited amounts of primary cells. Such an approach has the potential to improve our understanding of human biology and treating disease. In the future it may be possible to deploy novel stem cell-based approaches to treat human liver diseases. In recent years, efficient hepatic differentiation from human stem cells has been achieved by several research groups including our own. In this review we provide an overview of the field and discuss the future potential and limitations of stem cell technology. (C) 2012 Baishideng. All rights reserved.",

keywords = "Transplantation, GENE-EXPRESSION, Regenerative medicine, PROGENITOR CELLS, EFFICIENT DIFFERENTIATION, DEFINED FACTORS, MARROW STROMAL CELLS, HEPATIC OVAL CELLS, Differentiation, Liver development, Pluripotent stem cells, IN-VITRO, Polymer chemistry, HUMAN BLASTOCYSTS, HEPATOCYTE-LIKE CELLS, FUNCTIONAL HEPATOCYTES, Hepatocyte-like cells, Bio-artificial liver",

author = "Wen-Li Zhou and Medine, {Claire N.} and Liang Zhu and Hay, {David C.}",

year = "2012",

month = may,

day = "7",

doi = "10.3748/wjg.v18.i17.2018",

language = "English",

volume = "18",

pages = "2018--2025",

journal = "World Journal of Gastroenterology",

issn = "1007-9327",

publisher = "Baishideng Publishing Group",

number = "17",

}

TY - JOUR

T1 - Stem cell differentiation and human liver disease

AU - Zhou, Wen-Li

AU - Medine, Claire N.

AU - Zhu, Liang

AU - Hay, David C.

PY - 2012/5/7

Y1 - 2012/5/7

N2 - Human stem cells are scalable cell populations capable of cellular differentiation. This makes them a very attractive in vitro cellular resource and in theory provides unlimited amounts of primary cells. Such an approach has the potential to improve our understanding of human biology and treating disease. In the future it may be possible to deploy novel stem cell-based approaches to treat human liver diseases. In recent years, efficient hepatic differentiation from human stem cells has been achieved by several research groups including our own. In this review we provide an overview of the field and discuss the future potential and limitations of stem cell technology. (C) 2012 Baishideng. All rights reserved.

AB - Human stem cells are scalable cell populations capable of cellular differentiation. This makes them a very attractive in vitro cellular resource and in theory provides unlimited amounts of primary cells. Such an approach has the potential to improve our understanding of human biology and treating disease. In the future it may be possible to deploy novel stem cell-based approaches to treat human liver diseases. In recent years, efficient hepatic differentiation from human stem cells has been achieved by several research groups including our own. In this review we provide an overview of the field and discuss the future potential and limitations of stem cell technology. (C) 2012 Baishideng. All rights reserved.

KW - Transplantation

KW - GENE-EXPRESSION

KW - Regenerative medicine

KW - PROGENITOR CELLS

KW - EFFICIENT DIFFERENTIATION

KW - DEFINED FACTORS

KW - MARROW STROMAL CELLS

KW - HEPATIC OVAL CELLS

KW - Differentiation

KW - Liver development

KW - Pluripotent stem cells

KW - IN-VITRO

KW - Polymer chemistry

KW - HUMAN BLASTOCYSTS

KW - HEPATOCYTE-LIKE CELLS

KW - FUNCTIONAL HEPATOCYTES

KW - Hepatocyte-like cells

KW - Bio-artificial liver

U2 - 10.3748/wjg.v18.i17.2018

DO - 10.3748/wjg.v18.i17.2018

M3 - Literature review

VL - 18

SP - 2018

EP - 2025

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 17

ER -

Stem cell differentiation and human liver disease

Abstract

Keywords

Access to Document

Fingerprint

Cite this