Stem cells, signals and vertebrate body axis extension

Valerie Wilson, Isabel Olivera-Martinez, Kate G. Storey

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The progressive generation of chick and mouse axial tissues - the spinal cord, skeleton and musculature of the body - has long been proposed to depend on the activity of multipotent stem cells. Here, we evaluate evidence for the existence and multipotency of axial stem cells. We show that although the data strongly support their existence, there is little definitive information about their multipotency or extent of contribution to the axis. We also review the location and molecular characteristics of these putative stem cells, along with their evolutionary conservation in vertebrates and the signalling mechanisms that regulate and arrest axis extension.
Original languageEnglish
Pages (from-to)1591-604
Number of pages14
JournalDevelopment
Volume136
Issue number10
Early online date24 Apr 2009
DOIs
Publication statusPublished - 31 May 2009

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