Stemming Colorectal Cancer Growth and Metastasis: HOXA5 Forces Cancer Stem Cells to Differentiate

Si Hui Tan, Nick Barker

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Wnt signaling drives colorectal cancer stem cells, but effective therapeutics targeting these cells and their signaling pathways are lacking. In this issue of Cancer Cell, Ordóñez-Morán and colleagues describe a promising therapeutic intervention for colorectal cancers that selectively induces cancer stem cell differentiation through HOXA5 expression and Wnt signaling inhibition.

Original languageEnglish
Pages (from-to)683-5
Number of pages3
JournalCancer Cell
Volume28
Issue number6
DOIs
Publication statusPublished - 14 Dec 2015

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