Stemming Colorectal Cancer Growth and Metastasis: HOXA5 Forces Cancer Stem Cells to Differentiate

Si Hui Tan; Nick Barker

doi:10.1016/j.ccell.2015.11.004

Stemming Colorectal Cancer Growth and Metastasis: HOXA5 Forces Cancer Stem Cells to Differentiate

Si Hui Tan, Nick Barker

Research output: Contribution to journal › Literature review › peer-review

Abstract / Description of output

Wnt signaling drives colorectal cancer stem cells, but effective therapeutics targeting these cells and their signaling pathways are lacking. In this issue of Cancer Cell, Ordóñez-Morán and colleagues describe a promising therapeutic intervention for colorectal cancers that selectively induces cancer stem cell differentiation through HOXA5 expression and Wnt signaling inhibition.

Original language	English
Pages (from-to)	683-5
Number of pages	3
Journal	Cancer Cell
Volume	28
Issue number	6
DOIs	https://doi.org/10.1016/j.ccell.2015.11.004
Publication status	Published - 14 Dec 2015

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10.1016/j.ccell.2015.11.004

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@article{8cab2d7a658a459f9db5268a6d62e133,

title = "Stemming Colorectal Cancer Growth and Metastasis: HOXA5 Forces Cancer Stem Cells to Differentiate",

abstract = "Wnt signaling drives colorectal cancer stem cells, but effective therapeutics targeting these cells and their signaling pathways are lacking. In this issue of Cancer Cell, Ord{\'o}{\~n}ez-Mor{\'a}n and colleagues describe a promising therapeutic intervention for colorectal cancers that selectively induces cancer stem cell differentiation through HOXA5 expression and Wnt signaling inhibition.",

author = "Tan, {Si Hui} and Nick Barker",

year = "2015",

month = dec,

day = "14",

doi = "10.1016/j.ccell.2015.11.004",

language = "English",

volume = "28",

pages = "683--5",

journal = "Cancer Cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "6",

}

TY - JOUR

T1 - Stemming Colorectal Cancer Growth and Metastasis

T2 - HOXA5 Forces Cancer Stem Cells to Differentiate

AU - Tan, Si Hui

AU - Barker, Nick

PY - 2015/12/14

Y1 - 2015/12/14

N2 - Wnt signaling drives colorectal cancer stem cells, but effective therapeutics targeting these cells and their signaling pathways are lacking. In this issue of Cancer Cell, Ordóñez-Morán and colleagues describe a promising therapeutic intervention for colorectal cancers that selectively induces cancer stem cell differentiation through HOXA5 expression and Wnt signaling inhibition.

AB - Wnt signaling drives colorectal cancer stem cells, but effective therapeutics targeting these cells and their signaling pathways are lacking. In this issue of Cancer Cell, Ordóñez-Morán and colleagues describe a promising therapeutic intervention for colorectal cancers that selectively induces cancer stem cell differentiation through HOXA5 expression and Wnt signaling inhibition.

U2 - 10.1016/j.ccell.2015.11.004

DO - 10.1016/j.ccell.2015.11.004

M3 - Literature review

C2 - 26678334

SN - 1535-6108

VL - 28

SP - 683

EP - 685

JO - Cancer Cell

JF - Cancer Cell

IS - 6

ER -

Stemming Colorectal Cancer Growth and Metastasis: HOXA5 Forces Cancer Stem Cells to Differentiate

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