Stereodivergent Asymmetric Allylic Alkylation (AAA)

Subarna Jyoti Kalita, Uwe Schneider, Yi-Yong Huang

Research output: Contribution to journalArticlepeer-review

Abstract

This article highlights the recent conceptual advances in stereodivergent catalytic asymmetric allylic alkylation (AAA). Since an earlier breakthrough by Carreira and co-workers, the field of stereodivergent AAA has been dominated by synergistic dual catalysis, i.e., switching the absolute configuration of two distinct chiral catalysts (metal/organo or heterobimetallic) to access all four tereoisomeric
products. In this context, the most recent examples of this methodology have been highlighted, including a dynamic kinetic asymmetric transformation (DyKAT) reported by Liao and Zhang and co-workers in 2020. Significantly, the use of a single-chiral metal catalyst for the AAA, coupled with a stoichiometric a-fluorination in a sequencedependent diastereodivergent strategy, has been disclosed by You and co-workers in 2020. Most recently, the same group have uncovered an intriguing time-dependent enantiodivergent asymmetric allylic amination to give each enantiomeric product using a single-enantiomeric metal catalyst; via two sequential kinetic resolutions.
Original languageEnglish
JournalScience Bulletin
Volume65
Early online date2 Aug 2020
DOIs
Publication statusE-pub ahead of print - 2 Aug 2020

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