A new rhodium-catalyzed carbozincation of ynamides has been developed, using diorganozinc: reagents or functionatized alkylzinc: halides. The reactions are highly regio- and stereoselective, allowing access to a wide range of multisubstituted enamides, which are increasingly important building blocks for organic synthesis. Utilization of the alkenylzinc intermediates in further carbon-carbon bond-forming reactions to form trisubstituted enamides is also possible.
|Number of pages||3|
|Journal||Journal of the American Chemical Society|
|Publication status||Published - 25 Mar 2009|
- COUPLING REACTIONS
- CHIRAL ENAMIDES
- TERMINAL ALKYNES