Abstract
Human epidermis is renewed throughout life from stem cells in the basal layer of the epidermis. Signals from the surrounding keratinocytes influence the differentiation of the stem cells, but the nature of the signals is unknown. In many developing tissues, signalling mediated by the transmembrane protein Delta1 and its receptor Notch1 inhibits differentiation. Here, we investigated the role of Delta-Notch signalling in postnatal human epidermis.
Original language | English |
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Pages (from-to) | 491-500 |
Number of pages | 10 |
Journal | Current Biology |
Volume | 10 |
Issue number | 9 |
Publication status | Published - 2000 |
Keywords / Materials (for Non-textual outputs)
- Cell Differentiation
- Cells, Cultured
- Epidermis
- Fibroblasts
- Humans
- Intracellular Signaling Peptides and Proteins
- Keratinocytes
- Membrane Proteins
- Receptor, Notch1
- Receptors, Cell Surface
- Signal Transduction
- Stem Cells
- Transcription Factors