Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters

S Lowell, P Jones, I Le Roux, J Dunne, F M Watt

Research output: Contribution to journalArticlepeer-review

Abstract

Human epidermis is renewed throughout life from stem cells in the basal layer of the epidermis. Signals from the surrounding keratinocytes influence the differentiation of the stem cells, but the nature of the signals is unknown. In many developing tissues, signalling mediated by the transmembrane protein Delta1 and its receptor Notch1 inhibits differentiation. Here, we investigated the role of Delta-Notch signalling in postnatal human epidermis.
Original languageEnglish
Pages (from-to)491-500
Number of pages10
JournalCurrent Biology
Volume10
Issue number9
Publication statusPublished - 2000

Keywords

  • Cell Differentiation
  • Cells, Cultured
  • Epidermis
  • Fibroblasts
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Keratinocytes
  • Membrane Proteins
  • Receptor, Notch1
  • Receptors, Cell Surface
  • Signal Transduction
  • Stem Cells
  • Transcription Factors

Fingerprint

Dive into the research topics of 'Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters'. Together they form a unique fingerprint.

Cite this