Projects per year
Circadian clocks are gene regulatory networks whose role is to help the organisms to cope with variations in environmental conditions such as the day/night cycle. In this work, we explored the effects of molecular noise in single cells on the behaviour of the circadian clock in the plant model species Arabidopsis thaliana. The computational modelling language Bio-PEPA enabled us to give a stochastic interpretation of an existing deterministic model of the clock, and to easily compare the results obtained via stochastic simulation and via numerical solution of the deterministic model. First, the introduction of stochasticity in the model allowed us to estimate the unknown size of the system. Moreover, stochasticity improved the description of the available experimental data in several light conditions: noise-induced fluctuations yield a faster entrainment of the plant clock under certain photoperiods and are able to explain the experimentally observed dampening of the oscillations in plants under constant light conditions. The model predicts that the desynchronization between noisy oscillations in single cells contributes to the observed damped oscillations at the level of the cell population. Analysis of the phase, period and amplitude distributions under various light conditions demonstrated robust entrainment of the plant clock to light/dark cycles which closely matched the available experimental data.
|Journal||Journal of the Royal Society. Interface|
|Publication status||Published - 2011|
FingerprintDive into the research topics of 'Stochastic properties of the plant circadian clock'. Together they form a unique fingerprint.
- 4 Finished
TiMet: Linking the clock to metabolism
1/03/10 → 28/02/15
Regulation of biological signalling by temperature (ROBUST)
Halliday, K., Gilmore, S. & Millar, A.
14/04/08 → 13/10/13
SIGNAL: SIGNAL -Stochastic process algebra for biochemical signaling pathway analysis
1/09/07 → 31/01/11
- 1 Article
Data assimilation constrains new connections and components in a complex, eukaryotic circadian clock modelPokhilko, A., Hodge, S. K., Stratford, K., Knox, K., Edwards, K. D., Thomson, A. W., Mizuno, T. & Millar, A. J., 21 Sep 2010, In: Molecular Systems Biology. 6, 10 p., 416.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile
Plant Systems Modelling database
Millar, A. (Creator), University of Edinburgh, 2009
https://fairdomhub.org/projects/129 and one more link, http://www.plasmo.ed.ac.uk (show fewer)