Stop codon context modulates NMD efficiency through translation termination kinetics

Dasa Longman; Laura Monaghan; Javier F. Caceres

doi:10.1016/j.xgen.2025.100948

Stop codon context modulates NMD efficiency through translation termination kinetics

Dasa Longman, Laura Monaghan, Javier F. Caceres^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Nonsense-mediated mRNA decay efficiency varies unpredictably across transcripts
containing premature termination codons. A new study demonstrates that glycine
residues preceding stop codons create an extended translation termination window
that enhances NMD activity, offering new mechanistic explanations for NMD variability and improved clinical variant interpretation.

Original language	English
Journal	Cell Genomics
DOIs	https://doi.org/10.1016/j.xgen.2025.100948
Publication status	Published - 9 Jul 2025

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10.1016/j.xgen.2025.100948Licence: Creative Commons: Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

Stop codon context modulates NMD effici..Final published version, 465 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

RNA processing and gene regulation
Caceres, J. (Principal Investigator)
1/04/23 → 31/03/28
Project: Research

Cite this

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title = "Stop codon context modulates NMD efficiency through translation termination kinetics",

abstract = "Nonsense-mediated mRNA decay efficiency varies unpredictably across transcripts containing premature termination codons. A new study demonstrates that glycine residues preceding stop codons create an extended translation termination window that enhances NMD activity, offering new mechanistic explanations for NMD variability and improved clinical variant interpretation.",

author = "Dasa Longman and Laura Monaghan and Caceres, \{Javier F.\}",

year = "2025",

month = jul,

day = "9",

doi = "10.1016/j.xgen.2025.100948",

language = "English",

journal = "Cell Genomics",

issn = "2666-979X",

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TY - JOUR

T1 - Stop codon context modulates NMD efficiency through translation termination kinetics

AU - Longman, Dasa

AU - Monaghan, Laura

AU - Caceres, Javier F.

PY - 2025/7/9

Y1 - 2025/7/9

N2 - Nonsense-mediated mRNA decay efficiency varies unpredictably across transcripts containing premature termination codons. A new study demonstrates that glycine residues preceding stop codons create an extended translation termination window that enhances NMD activity, offering new mechanistic explanations for NMD variability and improved clinical variant interpretation.

AB - Nonsense-mediated mRNA decay efficiency varies unpredictably across transcripts containing premature termination codons. A new study demonstrates that glycine residues preceding stop codons create an extended translation termination window that enhances NMD activity, offering new mechanistic explanations for NMD variability and improved clinical variant interpretation.

U2 - 10.1016/j.xgen.2025.100948

DO - 10.1016/j.xgen.2025.100948

M3 - Comment/debate

SN - 2666-979X

JO - Cell Genomics

JF - Cell Genomics

ER -

Stop codon context modulates NMD efficiency through translation termination kinetics

Abstract

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RNA processing and gene regulation

Cite this