Strategies for p53 reactivation in human sarcoma

Ted R Hupp; Richard L Hayward; Borek Vojtesek

doi:10.1016/j.ccr.2012.08.020

Strategies for p53 reactivation in human sarcoma

Ted R Hupp, Richard L Hayward, Borek Vojtesek

Research output: Contribution to journal › Article

Abstract / Description of output

Emerging strategies in cancer therapeutics link the genomic mutational and proteomic landscape, allowing intelligent reasoning on target selection. In this issue of Cancer Cell, Piccinin and colleagues use this approach to demonstrate that the mesenchymal protein Twist1 inhibits p53, providing a novel target for reactivation of p53 in human sarcoma.

Original language	English
Pages (from-to)	283-5
Number of pages	3
Journal	Cancer Cell
Volume	22
Issue number	3
DOIs	https://doi.org/10.1016/j.ccr.2012.08.020
Publication status	Published - 2012

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10.1016/j.ccr.2012.08.020

http://www.cell.com/cancer-cell/retrieve/pii/S1535610812003613

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title = "Strategies for p53 reactivation in human sarcoma",

abstract = "Emerging strategies in cancer therapeutics link the genomic mutational and proteomic landscape, allowing intelligent reasoning on target selection. In this issue of Cancer Cell, Piccinin and colleagues use this approach to demonstrate that the mesenchymal protein Twist1 inhibits p53, providing a novel target for reactivation of p53 in human sarcoma.",

author = "Hupp, {Ted R} and Hayward, {Richard L} and Borek Vojtesek",

year = "2012",

doi = "10.1016/j.ccr.2012.08.020",

language = "English",

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journal = "Cancer Cell",

issn = "1535-6108",

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T1 - Strategies for p53 reactivation in human sarcoma

AU - Hupp, Ted R

AU - Hayward, Richard L

AU - Vojtesek, Borek

PY - 2012

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N2 - Emerging strategies in cancer therapeutics link the genomic mutational and proteomic landscape, allowing intelligent reasoning on target selection. In this issue of Cancer Cell, Piccinin and colleagues use this approach to demonstrate that the mesenchymal protein Twist1 inhibits p53, providing a novel target for reactivation of p53 in human sarcoma.

AB - Emerging strategies in cancer therapeutics link the genomic mutational and proteomic landscape, allowing intelligent reasoning on target selection. In this issue of Cancer Cell, Piccinin and colleagues use this approach to demonstrate that the mesenchymal protein Twist1 inhibits p53, providing a novel target for reactivation of p53 in human sarcoma.

U2 - 10.1016/j.ccr.2012.08.020

DO - 10.1016/j.ccr.2012.08.020

M3 - Article

C2 - 22975370

SN - 1535-6108

VL - 22

SP - 283

EP - 285

JO - Cancer Cell

JF - Cancer Cell

IS - 3

ER -

Strategies for p53 reactivation in human sarcoma

Abstract / Description of output

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