Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease

Irfan Rahman, Vuokko L Kinnula

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and morbidity globally, and its development is mainly associated with tobacco/biomass smoke-induced oxidative stress. Hence, targeting systemic and local oxidative stress with agents that can balance the antioxidant/redox system can be expected to be useful in the treatment of COPD. Preclinical and clinical trials have revealed that antioxidants/redox modulators can detoxify free radicals and oxidants, control expression of redox and glutathione biosynthesis genes, chromatin remodeling and inflammatory gene expression; and are especially useful in preventing COPD exacerbations. In this review, various novel approaches and problems associated with these approaches in COPD are reviewed.
Original languageEnglish
Pages (from-to)293-309
JournalExpert Review of Clinical Pharmacology
Volume5
Issue number3
DOIs
Publication statusPublished - May 2012

Keywords

  • Antioxidants
  • COPD
  • Glutathione
  • Nrf2
  • Oxidants
  • REDOX
  • Thiol
  • tobacco smoke

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