Abstract
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and morbidity globally, and its development is mainly associated with tobacco/biomass smoke-induced oxidative stress. Hence, targeting systemic and local oxidative stress with agents that can balance the antioxidant/redox system can be expected to be useful in the treatment of COPD. Preclinical and clinical trials have revealed that antioxidants/redox modulators can detoxify free radicals and oxidants, control expression of redox and glutathione biosynthesis genes, chromatin remodeling and inflammatory gene expression; and are especially useful in preventing COPD exacerbations. In this review, various novel approaches and problems associated with these approaches in COPD are reviewed.
Original language | English |
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Pages (from-to) | 293-309 |
Journal | Expert Review of Clinical Pharmacology |
Volume | 5 |
Issue number | 3 |
DOIs | |
Publication status | Published - May 2012 |
Keywords / Materials (for Non-textual outputs)
- Antioxidants
- COPD
- Glutathione
- Nrf2
- Oxidants
- REDOX
- Thiol
- tobacco smoke