Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer

Alexander Henke; O Cathal Grace; George R Ashley; Grant D Stewart; Antony C P Riddick; Henry Yeun; Marie O'Donnell; Richard A Anderson; Axel A Thomson

doi:10.1371/journal.pone.0042516

Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer

Alexander Henke, O Cathal Grace, George R Ashley, Grant D Stewart, Antony C P Riddick, Henry Yeun, Marie O'Donnell, Richard A Anderson, Axel A Thomson

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

During prostate development, mesenchymal-epithelial interactions regulate organ growth and differentiation. In adult prostate, stromal-epithelial interactions are important for tissue homeostasis and also play a significant role in prostate cancer. In this study we have identified molecules that show a mesenchymal expression pattern in the developing prostate, and one of these showed reduced expression in prostate cancer stroma.

Original language	English
Pages (from-to)	e42516
Journal	PLoS ONE
Volume	7
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0042516
Publication status	Published - 2012

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10.1371/journal.pone.0042516

Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer
Copyright: © Henke et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0042516

Cite this

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title = "Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer",

abstract = "During prostate development, mesenchymal-epithelial interactions regulate organ growth and differentiation. In adult prostate, stromal-epithelial interactions are important for tissue homeostasis and also play a significant role in prostate cancer. In this study we have identified molecules that show a mesenchymal expression pattern in the developing prostate, and one of these showed reduced expression in prostate cancer stroma.",

author = "Alexander Henke and Grace, {O Cathal} and Ashley, {George R} and Stewart, {Grant D} and Riddick, {Antony C P} and Henry Yeun and Marie O'Donnell and Anderson, {Richard A} and Thomson, {Axel A}",

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AU - Henke, Alexander

AU - Grace, O Cathal

AU - Ashley, George R

AU - Stewart, Grant D

AU - Riddick, Antony C P

AU - Yeun, Henry

AU - O'Donnell, Marie

AU - Anderson, Richard A

AU - Thomson, Axel A

PY - 2012

Y1 - 2012

N2 - During prostate development, mesenchymal-epithelial interactions regulate organ growth and differentiation. In adult prostate, stromal-epithelial interactions are important for tissue homeostasis and also play a significant role in prostate cancer. In this study we have identified molecules that show a mesenchymal expression pattern in the developing prostate, and one of these showed reduced expression in prostate cancer stroma.

AB - During prostate development, mesenchymal-epithelial interactions regulate organ growth and differentiation. In adult prostate, stromal-epithelial interactions are important for tissue homeostasis and also play a significant role in prostate cancer. In this study we have identified molecules that show a mesenchymal expression pattern in the developing prostate, and one of these showed reduced expression in prostate cancer stroma.

U2 - 10.1371/journal.pone.0042516

DO - 10.1371/journal.pone.0042516

M3 - Article

C2 - 22880013

SN - 1932-6203

VL - 7

SP - e42516

JO - PLoS ONE

JF - PLoS ONE

IS - 8

ER -

Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer

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