Strong-coupling dynamics of a multicellular chemotactic system

R Grima*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Chemical signaling is one of the ubiquitous mechanisms by which intercellular communication takes place at the microscopic level, particularly via chemotaxis. Such multicellular systems are popularly studied using continuum, mean-field equations. In this Letter we study a stochastic model of chemotactic signaling. The Langevin formalism of the model makes it amenable to calculation via nonperturbative analysis, which enables a quantification of the effect of fluctuations on both the weak and the strongly coupled biological dynamics. In particular, we show that the (i) self-localization due to autochemotaxis is impossible. (ii) When aggregation occurs, the aggregate performs a random walk with a renormalized diffusion coefficient D-R proportional to epsilon(-2)N(-3). (iii) The stochastic model exhibits sharp transitions in cell motile behavior for negative chemotaxis, behavior that has no parallel in the mean-field Keller-Segel equations.

Original languageEnglish
Article number128103
Number of pages4
JournalPhysical Review Letters
Volume95
Issue number12
DOIs
Publication statusPublished - 16 Sep 2005

Keywords

  • AGGREGATION
  • DICTYOSTELIUM

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