Stronger Computational Modelling of Signalling Pathways Using Both Continuous and Discrete-State Methods

Muffy Calder, Adam Duguid, Stephen Gilmore, Jane Hillston

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Starting from a biochemical signalling pathway model expressed in a process algebra enriched with quantitative information we automatically derive both continuous-space and discrete-state representations suitable for numerical evaluation. We compare results obtained using implicit numerical differentiation formulae to those obtained using approximate stochastic simulation thereby exposing a flaw in the use of the differentiation procedure producing misleading results.
Original languageEnglish
Title of host publicationComputational Methods in Systems Biology
Subtitle of host publicationInternational Conference, CMSB 2006, Trento, Italy, October 18-19, 2006. Proceedings
EditorsCorrado Priami
PublisherSpringer-Verlag GmbH
Pages63-77
Number of pages15
ISBN (Electronic)978-3-540-46167-8
ISBN (Print)978-3-540-46166-1
DOIs
Publication statusPublished - 2006

Publication series

NameLecture Notes in Computer Science
PublisherSpringer Berlin / Heidelberg
Volume4210
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

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