Structural variants at the BRCA1/2 loci are a common source of homologous repair deficiency in high grade serous ovarian carcinoma

Ailith Ewing; Alison M Meynert; Michael Churchman; Graeme R Grimes; Robb Hollis; C Simon Herrington; Tzyvia Rye; Clare  Bartos; Ian Croy; Michelle Ferguson; Mairi Lennie; Trevor McGoldrick; Neil McPhail; Nadeem Siddiqui; Suzanne Dowson; Rosalind Glasspool; Melanie MacKean; Fiona Nussey; Brian McDade; Darren Ennis; The Scottish Genomes Partnership; Lynn McMahon; Athena Matakidou; Brian Dougherty; Ruth March; J. Carl Barrett; Iain A. McNeish; Andrew V. Biankin; Patricia Roxburgh; Charlie Gourley; Colin A Semple

doi:10.1158/1078-0432.CCR-20-4068

Structural variants at the BRCA1/2 loci are a common source of homologous repair deficiency in high grade serous ovarian carcinoma

Ailith Ewing, Alison M Meynert, Michael Churchman, Graeme R Grimes, Robb Hollis, C Simon Herrington, Tzyvia Rye, Clare Bartos, Ian Croy, Michelle Ferguson, Mairi Lennie, Trevor McGoldrick, Neil McPhail, Nadeem Siddiqui, Suzanne Dowson, Rosalind Glasspool, Melanie MacKean, Fiona Nussey, Brian McDade, Darren EnnisThe Scottish Genomes Partnership, Lynn McMahon, Athena Matakidou, Brian Dougherty, Ruth March, J. Carl Barrett, Iain A. McNeish, Andrew V. Biankin, Patricia Roxburgh, Charlie Gourley, Colin A Semple

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Clinical Cancer Research
DOIs	https://doi.org/10.1158/1078-0432.CCR-20-4068
Publication status	Published - 1 Jun 2021

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10.1158/1078-0432.CCR-20-4068

BRCA SV CCR 2021
This is a pre-copyedited, author-produced version of an article accepted for publication in Clinical Cancer Research following peer review. The version of record "Structural variants at the BRCA1/2 loci are a common source of homologous repair deficiency in high grade serous ovarian carcinoma" is available online at: https://clincancerres.aacrjournals.org/content/early/2021/03/18/1078-0432.CCR-20-4068 & DOI: 10.1158/1078-0432.CCR-20-4068
Accepted author manuscript, 2.09 MB

Medical and Regulatory Genomics
Semple, C.
1/04/18 → 31/03/23
Project: Research

Bioinformatics Analysis Core
Alison Meynert (Manager), Murray Wham (Other), Kevin Donnelly (Other), Mihail Halachev (Other) & Hannes Becher (Other)
Deanery of Molecular, Genetic and Population Health Sciences
Facility/equipment: Facility

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Ewing, A., Meynert, A. M., Churchman, M., Grimes, G. R., Hollis, R., Herrington, C. S., Rye, T., Bartos, C., Croy, I., Ferguson, M., Lennie, M., McGoldrick, T., McPhail, N., Siddiqui, N., Dowson, S., Glasspool, R., MacKean, M., Nussey, F., McDade, B., ... Semple, C. A. (2021). Structural variants at the BRCA1/2 loci are a common source of homologous repair deficiency in high grade serous ovarian carcinoma. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-4068

@article{dedda977319f406b9fafb439936e6884,

title = "Structural variants at the BRCA1/2 loci are a common source of homologous repair deficiency in high grade serous ovarian carcinoma",

author = "Ailith Ewing and Meynert, {Alison M} and Michael Churchman and Grimes, {Graeme R} and Robb Hollis and Herrington, {C Simon} and Tzyvia Rye and Clare Bartos and Ian Croy and Michelle Ferguson and Mairi Lennie and Trevor McGoldrick and Neil McPhail and Nadeem Siddiqui and Suzanne Dowson and Rosalind Glasspool and Melanie MacKean and Fiona Nussey and Brian McDade and Darren Ennis and {The Scottish Genomes Partnership} and Lynn McMahon and Athena Matakidou and Brian Dougherty and Ruth March and Barrett, {J. Carl} and {A. McNeish}, Iain and {V. Biankin}, Andrew and Patricia Roxburgh and Charlie Gourley and Semple, {Colin A} and Javier Santoyo-Lopez",

year = "2021",

month = jun,

day = "1",

doi = "10.1158/1078-0432.CCR-20-4068",

language = "English",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research Inc.",

}

Ewing, A , Meynert, AM , Churchman, M, Grimes, GR, Hollis, R , Herrington, CS, Rye, T, Bartos, C, Croy, I, Ferguson, M, Lennie, M, McGoldrick, T, McPhail, N, Siddiqui, N, Dowson, S, Glasspool, R, MacKean, M, Nussey, F, McDade, B, Ennis, D, The Scottish Genomes Partnership, McMahon, L, Matakidou, A, Dougherty, B, March, R, Barrett, JC, A. McNeish, I, V. Biankin, A, Roxburgh, P, Gourley, C & Semple, CA 2021, 'Structural variants at the BRCA1/2 loci are a common source of homologous repair deficiency in high grade serous ovarian carcinoma', Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-4068

TY - JOUR

T1 - Structural variants at the BRCA1/2 loci are a common source of homologous repair deficiency in high grade serous ovarian carcinoma

AU - Ewing, Ailith

AU - Meynert, Alison M

AU - Churchman, Michael

AU - Grimes, Graeme R

AU - Hollis, Robb

AU - Herrington, C Simon

AU - Rye, Tzyvia

AU - Bartos, Clare

AU - Croy, Ian

AU - Ferguson, Michelle

AU - Lennie, Mairi

AU - McGoldrick, Trevor

AU - McPhail, Neil

AU - Siddiqui, Nadeem

AU - Dowson, Suzanne

AU - Glasspool, Rosalind

AU - MacKean, Melanie

AU - Nussey, Fiona

AU - McDade, Brian

AU - Ennis, Darren

AU - The Scottish Genomes Partnership

AU - McMahon, Lynn

AU - Matakidou, Athena

AU - Dougherty, Brian

AU - March, Ruth

AU - Barrett, J. Carl

AU - A. McNeish, Iain

AU - V. Biankin, Andrew

AU - Roxburgh, Patricia

AU - Gourley, Charlie

AU - Semple, Colin A

A2 - Santoyo-Lopez, Javier

PY - 2021/6/1

Y1 - 2021/6/1

U2 - 10.1158/1078-0432.CCR-20-4068

DO - 10.1158/1078-0432.CCR-20-4068

M3 - Article

SN - 1078-0432

JO - Clinical Cancer Research

JF - Clinical Cancer Research

ER -

Structural variants at the BRCA1/2 loci are a common source of homologous repair deficiency in high grade serous ovarian carcinoma

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Projects

Medical and Regulatory Genomics

Equipment

Bioinformatics Analysis Core

Cite this