Structure-activity relationships in beta-defensin peptides

K. Taylor; P. E. Barran; Julia Dorin

doi:10.1002/bip.20900

Structure-activity relationships in beta-defensin peptides

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The β-defensins comprise a large family of small cationic antimicrobial peptides widely distributed in plants, mammals and insects. These cysteine rich peptides display multifunctional properties with implications as potential therapeutic agents. Recent research has highlighted their role in both the innate and adaptive immune systems as well as being novel melanocortin ligands. Studies investigating structure and function provide an insight into the molecular basis of their immunological properties.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Peptide Science
Volume	90
Issue number	1
DOIs	https://doi.org/10.1002/bip.20900
Publication status	Published - Jan 2008

Keywords / Materials (for Non-textual outputs)

defensin
antimicrobial
structure/activity

Access to Document

10.1002/bip.20900

http://onlinelibrary.wiley.com/doi/10.1002/bip.20900/abstract

Team defensin: Platform: Model peptides to novel antibiotics: synthesis form and activity
Barran, P.
EPSRC
3/10/05 → 2/10/10
Project: Research

Cite this

@article{36edfd2b8706445b827750116ce6199e,

title = "Structure-activity relationships in beta-defensin peptides",

abstract = "The β-defensins comprise a large family of small cationic antimicrobial peptides widely distributed in plants, mammals and insects. These cysteine rich peptides display multifunctional properties with implications as potential therapeutic agents. Recent research has highlighted their role in both the innate and adaptive immune systems as well as being novel melanocortin ligands. Studies investigating structure and function provide an insight into the molecular basis of their immunological properties.",

keywords = "defensin, antimicrobial, structure/activity",

author = "K. Taylor and Barran, {P. E.} and Julia Dorin",

year = "2008",

month = jan,

doi = "10.1002/bip.20900",

language = "English",

volume = "90",

pages = "1--7",

journal = "Peptide Science",

issn = "2475-8817",

publisher = "Wiley",

number = "1",

}

TY - JOUR

T1 - Structure-activity relationships in beta-defensin peptides

AU - Taylor, K.

AU - Barran, P. E.

AU - Dorin, Julia

PY - 2008/1

Y1 - 2008/1

N2 - The β-defensins comprise a large family of small cationic antimicrobial peptides widely distributed in plants, mammals and insects. These cysteine rich peptides display multifunctional properties with implications as potential therapeutic agents. Recent research has highlighted their role in both the innate and adaptive immune systems as well as being novel melanocortin ligands. Studies investigating structure and function provide an insight into the molecular basis of their immunological properties.

AB - The β-defensins comprise a large family of small cationic antimicrobial peptides widely distributed in plants, mammals and insects. These cysteine rich peptides display multifunctional properties with implications as potential therapeutic agents. Recent research has highlighted their role in both the innate and adaptive immune systems as well as being novel melanocortin ligands. Studies investigating structure and function provide an insight into the molecular basis of their immunological properties.

KW - defensin

KW - antimicrobial

KW - structure/activity

U2 - 10.1002/bip.20900

DO - 10.1002/bip.20900

M3 - Article

SN - 2475-8817

VL - 90

SP - 1

EP - 7

JO - Peptide Science

JF - Peptide Science

IS - 1

ER -

Structure-activity relationships in beta-defensin peptides

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Projects

Team defensin: Platform: Model peptides to novel antibiotics: synthesis form and activity

Cite this