Structure and function of Per-ARNT-Sim domains and their possible role in the life-cycle biology of Trypanosoma cruzi

Maura Rojas-Pirela, Daniel J. Rigden, Paul A. Michels, Ana J. Cáceres, Juan Luis Concepción, Wilfredo Quiñones*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Per-ARNT-Sim (PAS) domains of proteins play important roles as modules for signalling and cellular regulation processes in widely diverse organisms such as Archaea, Bacteria, protists, plants, yeasts, insects and vertebrates. These domains are present in many proteins where they are used as sensors of stimuli and modules for protein interactions. Characteristically, they can bind a broad spectrum of molecules. Such binding causes the domain to trigger a specific cellular response or to make the protein containing the domain susceptible to responding to additional physical or chemical signals. Different PAS proteins have the ability to sense redox potential, light, oxygen, energy levels, carboxylic acids, fatty acids and several other stimuli. Such proteins have been found to be involved in cellular processes such as development, virulence, sporulation, adaptation to hypoxia, circadian cycle, metabolism and gene regulation and expression. Our analysis of the genome of different kinetoplastid species revealed the presence of PAS domains also in different predicted kinases from these protists. Open-reading frames coding for these PAS-kinases are unusually large. In addition, the products of these genes appear to contain in their structure combinations of domains uncommon in other eukaryotes. The physiological significance of PAS domains in these parasites, specifically in Trypanosoma cruzi, is discussed.

Original languageEnglish
Pages (from-to)52-66
Number of pages15
JournalMolecular and Biochemical Parasitology
Volume219
Early online date11 Nov 2017
DOIs
Publication statusPublished - Jan 2018

Keywords

  • Cell regulators
  • Glycosome
  • PAS domains functions
  • Per-ARNT-Sim (PAS) domains
  • Phosphoglycerate kinase like

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