Structure anti chromosomal mapping of the TNF-α inducible endothelial protein 1 (Edp1) gene in the mouse

Sally Swift, Clare Blackburn, Grant Morahan, Alan Ashworth*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

EDP1 was identified as a human gene activated transcriptionally by tumour necrosis factor α in endothelial cells. Here we have characterised the mouse Edp1 gene. We show that the gene encodes a highly conserved protein and describe its intron/exon structure. The presence of related genes in the sequence databases suggests that Edp1 is part of a gene family. Fine mapping of the gene in the mouse genome indicates that, as expected from its location on human chromosome 17, the mouse Edp1 gene maps to mouse chromosome 11. However, surprisingly, the gene does not map to the expected region of mouse chromosome 11 suggesting that a change in the order of genes has occurred within a conserved linkage group.

Original languageEnglish
Pages (from-to)394-398
Number of pages5
JournalBBA - Gene Structure and Expression
Volume1442
Issue number2-3
DOIs
Publication statusPublished - 8 Nov 1998

Keywords

  • (C. elegans)
  • Endothelial cell
  • Gene family
  • Gene structure
  • Mouse genome
  • Tumor necrosis factor α

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