Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice

P J Russell, J Cahill, F Cameron, D Hume

Research output: Contribution to journalArticlepeer-review

Abstract

The numbers of resident peritoneal cells recovered from NZB and (NZB X NZW)F1 hybrid mice, which develop systemic lupus erythematosus (SLE), increased strikingly with age as compared with cells recovered from normal mice. The rise paralleled the onset of anti-DNA antibodies, occurring earlier in females than in males. The increased number of cells was due to an accumulation of medium-sized cells with an indeterminate appearance, but with the functional characteristics and cell markers typical of a macrophage. The unusual cells were esterase, F4/80 and Mac-1 positive, peroxidase, and Alcian blue negative, and were shown on sedimentation velocity separation to be phagocytic for EA and C3 (serum-treated) zymosan; 47-48% of peritoneal cells were Ia positive.
Original languageEnglish
Pages (from-to)241-54
Number of pages14
JournalJournal of Leukocyte Biology
Volume38
Issue number2
Publication statusPublished - Aug 1985

Keywords

  • Age Factors
  • Animals
  • Antibodies, Monoclonal
  • Antigens, Surface
  • Ascitic Fluid
  • Autoantibodies
  • DNA
  • Disease Models, Animal
  • Esterases
  • Female
  • Heterozygote
  • Lupus Erythematosus, Systemic
  • Macrophage Activation
  • Macrophages
  • Male
  • Mice
  • Mice, Inbred NZB
  • Peroxidases

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