Study protocol - A systematic review and meta-analysis of hypothermia in experimental traumatic brain injury: Why have promising animal studies not been replicated in pragmatic clinical trials?

Theodore C. Hirst, Ralf Watzlawick, Jonathan K. Rhodes, Malcolm R. Macleod, Peter J.d. Andrews

Research output: Contribution to journalArticlepeer-review

Abstract

Traumatic brain injury (TBI) is a major cause of death and permanent disability. Systemic hypothermia, a treatment used in TBI for many decades, has recently been found to be associated with neutral or unfavourable clinical outcomes despite apparently promising preclinical research. Systematic review and meta-analysis is a tool to summarize literature and observe trends in experimental design and quality that underpin its general conclusions. Here we aim to use these techniques to describe the use of hypothermia in animal TBI models, collating data relating to outcome and both study design and quality. From here we intend to observe correlations between features and attempt to explain any discrepancies found between animal and clinical data. This protocol describes the relevant methodology in detail.
Original languageEnglish
Article numbere00020
JournalEvidence-based Preclinical Medicine
Volume3
Issue number2
Early online date18 Oct 2016
DOIs
Publication statusE-pub ahead of print - 18 Oct 2016

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