Sublethal infection of C57BL/6 mice with Salmonella enterica serovar typhimurium leads to an increase in levels of toll-like receptor 1 (TLR1), TLR2, and TLR9 mRNA as well as a decrease in levels of TLR6 mRNA in infected organs

Sabine Tötemeyer, Pete Kaiser, Duncan J Maskell, Clare E Bryant

Research output: Contribution to journalArticlepeer-review

Abstract

Sublethal infection of C57BL/6 mice with Salmonella enterica serovar Typhimurium M525P initiates a strong inflammatory response. We measured organ expression of mRNA for Toll-like receptors and their associated signaling molecules during S. enterica serovar Typhimurium infection. During infection, the Toll-lie receptor 1 (TLR1), TLR2, and TLR9 mRNA levels increased, while TLR6 mRNA expression decreased.

Original languageEnglish
Pages (from-to)1873-1878
Number of pages6
JournalInfection and Immunity
Volume73
Issue number3
DOIs
Publication statusPublished - Mar 2005

Keywords

  • Animals
  • DNA-Binding Proteins
  • Down-Regulation
  • Membrane Glycoproteins
  • Mice
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Organ Specificity
  • Receptors, Cell Surface
  • Salmonella Infections, Animal
  • Salmonella typhimurium
  • Toll-Like Receptor 1
  • Toll-Like Receptor 2
  • Toll-Like Receptor 6
  • Toll-Like Receptor 9
  • Toll-Like Receptors
  • Up-Regulation

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