Successful induction of ovine pulmonary adenocarcinoma in lambs of different ages and detection of viraemia during the preclinical period

Daniela Salvatori, Lorenzo Gonzales, Patricia Dewar, Christina Cousens, Marcelo de las Heras, Robert Dalziel, J. Michael Sharp

Research output: Contribution to journalArticlepeer-review

Abstract

Ovine pulmonary adenocarcinoma (OPA) can be reproduced consistently in neonatal lambs by intratracheal injection of inocula containing jaagsiekte sheep retrovirus (JSRV). In this study, clinical disease, confirmed pathologically as OPA, was induced in a high proportion of lambs that had been inoculated intratracheally with infectious lung fluid at 1, 3 and 6 months of age. The incubation periods, however, were longer in these three age groups than in 1-week-old lambs that were used as controls. Viraemia was detected in all age groups before onset of clinical signs, but occurred later in older animals. These results suggest an age-dependent susceptibility to OPA that could be determined by the availability of JSRV target cells in the ovine lung. The feasibility of inducing OPA in older lambs and detecting JSRV viraemia in preclinical stages enables improved studies on the pathogenesis, assessment of vaccines, diagnosis and control of the disease.
Original languageEnglish
Article number11
Pages (from-to)3319-24
Number of pages6
JournalJournal of General Virology
Volume85
Publication statusPublished - Nov 2004

Keywords

  • Age Factors
  • Animals
  • Animals, Newborn
  • Disease Models, Animal
  • Jaagsiekte sheep retrovirus
  • Pulmonary Adenomatosis, Ovine/pathology
  • Pulmonary Adenomatosis, Ovine/virology
  • Sheep
  • Time Factors
  • Viremia/virology

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