Successful management of a unilateral persistent epithelial defect secondary to meibomian gland dysfunction in an Irish Sports Horse using a multi-modal treatment plan

Susie K. Armstrong; Benjamin Blacklock; John Keen; Fraser S.  Peck

doi:10.1002/vrc2.496

Successful management of a unilateral persistent epithelial defect secondary to meibomian gland dysfunction in an Irish Sports Horse using a multi-modal treatment plan

Susie K. Armstrong^*, Benjamin Blacklock, John Keen, Fraser S. Peck

^*Corresponding author for this work

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

A novel equine multi-modal protocol was implemented for management of unilateral equine dry eye disease and worsening persistent epithelial defects in a clinically well Irish Sports Horse. Utilising knowledge directly from human ophthalmic medicine for meibomian gland dysfunction, the meibomian glands were first mechanically debrided and expressed.
Then a four-point treatment protocol was instigated. The protocol comprised hot compressing, artificial tears, autologous serum and a topical azithromycin
regimen, resulting in a significant improvement in persistent epithelial defects and
clinical signs. This case highlights the benefits of a treatment plan containing both nonpharmacological and pharmacological therapies targeting the lipid component of the tear film matrix in horses with dry eye disease.

Original language	English
Article number	e496
Pages (from-to)	1-7
Number of pages	7
Journal	Vet Record Case Reports
Volume	10
Issue number	4
Early online date	21 Sept 2022
DOIs	https://doi.org/10.1002/vrc2.496
Publication status	Published - Dec 2022

Access to Document

10.1002/vrc2.496Licence: Creative Commons: Attribution (CC-BY)

Armstrong_July_2022_accepted_manuscriptAccepted author manuscript, 5.27 MBLicence: Creative Commons: Attribution Non-Commercial (CC-BY-NC)
Vet Record Case Reports - 2022 - Armstrong - Successful management of a unilateral persistent epithelial defect secondary (1)Final published version, 1.34 MBLicence: Creative Commons: Attribution (CC-BY)

Cite this

@article{7e288120055b477892897036033296c4,

title = "Successful management of a unilateral persistent epithelial defect secondary to meibomian gland dysfunction in an Irish Sports Horse using a multi-modal treatment plan",

abstract = "A novel equine multi-modal protocol was implemented for management of unilateral equine dry eye disease and worsening persistent epithelial defects in a clinically well Irish Sports Horse. Utilising knowledge directly from human ophthalmic medicine for meibomian gland dysfunction, the meibomian glands were first mechanically debrided and expressed. Then a four-point treatment protocol was instigated. The protocol comprised hot compressing, artificial tears, autologous serum and a topical azithromycinregimen, resulting in a significant improvement in persistent epithelial defects andclinical signs. This case highlights the benefits of a treatment plan containing both nonpharmacological and pharmacological therapies targeting the lipid component of the tear film matrix in horses with dry eye disease.",

author = "Armstrong, {Susie K.} and Benjamin Blacklock and John Keen and Peck, {Fraser S.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Veterinary Record Case Reports published by John Wiley & Sons Ltd on behalf of British Veterinary Association.",

year = "2022",

month = dec,

doi = "10.1002/vrc2.496",

language = "English",

volume = "10",

pages = "1--7",

journal = "Vet Record Case Reports",

issn = "2052-6121",

publisher = "Wiley",

number = "4",

}

TY - JOUR

T1 - Successful management of a unilateral persistent epithelial defect secondary to meibomian gland dysfunction in an Irish Sports Horse using a multi-modal treatment plan

AU - Armstrong, Susie K.

AU - Blacklock, Benjamin

AU - Keen, John

AU - Peck, Fraser S.

PY - 2022/12

Y1 - 2022/12

N2 - A novel equine multi-modal protocol was implemented for management of unilateral equine dry eye disease and worsening persistent epithelial defects in a clinically well Irish Sports Horse. Utilising knowledge directly from human ophthalmic medicine for meibomian gland dysfunction, the meibomian glands were first mechanically debrided and expressed. Then a four-point treatment protocol was instigated. The protocol comprised hot compressing, artificial tears, autologous serum and a topical azithromycinregimen, resulting in a significant improvement in persistent epithelial defects andclinical signs. This case highlights the benefits of a treatment plan containing both nonpharmacological and pharmacological therapies targeting the lipid component of the tear film matrix in horses with dry eye disease.

AB - A novel equine multi-modal protocol was implemented for management of unilateral equine dry eye disease and worsening persistent epithelial defects in a clinically well Irish Sports Horse. Utilising knowledge directly from human ophthalmic medicine for meibomian gland dysfunction, the meibomian glands were first mechanically debrided and expressed. Then a four-point treatment protocol was instigated. The protocol comprised hot compressing, artificial tears, autologous serum and a topical azithromycinregimen, resulting in a significant improvement in persistent epithelial defects andclinical signs. This case highlights the benefits of a treatment plan containing both nonpharmacological and pharmacological therapies targeting the lipid component of the tear film matrix in horses with dry eye disease.

U2 - 10.1002/vrc2.496

DO - 10.1002/vrc2.496

M3 - Article

SN - 2052-6121

VL - 10

SP - 1

EP - 7

JO - Vet Record Case Reports

JF - Vet Record Case Reports

IS - 4

M1 - e496

ER -

Successful management of a unilateral persistent epithelial defect secondary to meibomian gland dysfunction in an Irish Sports Horse using a multi-modal treatment plan

Abstract

Access to Document

Fingerprint

Cite this