Succinate: a new epigenetic hacker

Ming Yang; Patrick J Pollard

doi:10.1016/j.ccr.2013.05.015

Succinate: a new epigenetic hacker

Ming Yang, Patrick J Pollard

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Epigenetic reprogramming is a feature of many human cancers. In this issue of Cancer Cell, Letouzé and colleagues describe DNA hypermethylation in paragangliomas harboring mutations in succinate dehydrogenase genes. These tumors accumulate succinate, which inhibits 2-oxoglutarate-dependent histone and DNA demethylase enzymes, resulting in epigenetic silencing that affects neuroendocrine differentiation.

Original language	English
Pages (from-to)	709-11
Number of pages	3
Journal	Cancer Cell
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/j.ccr.2013.05.015
Publication status	Published - 10 Jun 2013

Keywords

Animals
DNA Methylation
Female
Humans
Male
Paraganglioma
Succinate Dehydrogenase

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10.1016/j.ccr.2013.05.015

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title = "Succinate: a new epigenetic hacker",

abstract = "Epigenetic reprogramming is a feature of many human cancers. In this issue of Cancer Cell, Letouz{\'e} and colleagues describe DNA hypermethylation in paragangliomas harboring mutations in succinate dehydrogenase genes. These tumors accumulate succinate, which inhibits 2-oxoglutarate-dependent histone and DNA demethylase enzymes, resulting in epigenetic silencing that affects neuroendocrine differentiation.",

keywords = "Animals, DNA Methylation, Female, Humans, Male, Paraganglioma, Succinate Dehydrogenase",

author = "Ming Yang and Pollard, {Patrick J}",

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journal = "Cancer Cell",

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AU - Pollard, Patrick J

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AB - Epigenetic reprogramming is a feature of many human cancers. In this issue of Cancer Cell, Letouzé and colleagues describe DNA hypermethylation in paragangliomas harboring mutations in succinate dehydrogenase genes. These tumors accumulate succinate, which inhibits 2-oxoglutarate-dependent histone and DNA demethylase enzymes, resulting in epigenetic silencing that affects neuroendocrine differentiation.

KW - Animals

KW - DNA Methylation

KW - Female

KW - Humans

KW - Male

KW - Paraganglioma

KW - Succinate Dehydrogenase

U2 - 10.1016/j.ccr.2013.05.015

DO - 10.1016/j.ccr.2013.05.015

M3 - Article

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VL - 23

SP - 709

EP - 711

JO - Cancer Cell

JF - Cancer Cell

SN - 1535-6108

IS - 6

ER -

Succinate: a new epigenetic hacker

Abstract

Keywords

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