Succinate: a new epigenetic hacker

Ming Yang, Patrick J Pollard

Research output: Contribution to journalArticlepeer-review


Epigenetic reprogramming is a feature of many human cancers. In this issue of Cancer Cell, Letouzé and colleagues describe DNA hypermethylation in paragangliomas harboring mutations in succinate dehydrogenase genes. These tumors accumulate succinate, which inhibits 2-oxoglutarate-dependent histone and DNA demethylase enzymes, resulting in epigenetic silencing that affects neuroendocrine differentiation.
Original languageEnglish
Pages (from-to)709-11
Number of pages3
JournalCancer Cell
Issue number6
Publication statusPublished - 10 Jun 2013


  • Animals
  • DNA Methylation
  • Female
  • Humans
  • Male
  • Paraganglioma
  • Succinate Dehydrogenase


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