TY - JOUR
T1 - Sudden Unexpected Death From Oligodendroglioma A Case Report and Review of the Literature
AU - Manousaki, Maria
AU - Papadaki, Helen
AU - Papavdi, Asteria
AU - Kranioti, Elena F.
AU - Mylonakis, Panagiotis
AU - Varakis, John
AU - Michalodimitrakis, Manolis
PY - 2011/12
Y1 - 2011/12
N2 - Sudden and unexpected deaths due to asymptomatic 5 primary brain tumors are extremely rare, with an incidence that ranges from 0.16 to 3.2%. Usually, such tumors are glioblastomas or, less commonly, astrocytomas. Asymptomatic oligodendrogliomas causing sudden death are hardly ever reported among medico-legal investigated cases.We report a rare case of sudden and unexpected death from a previously asymptomatic and undiagnosed, well-differentiated, grade II oligodendrogloioma (WHO classification). According to the autopsy and the microscopic findings brain edema as a result of obstruction of the cerebrospinal fluid flow due to hemorrhagic leakage of the oligodendroglioma is incriminated as the most probable physiopathological mechanism for the sudden death. Diagnosis is mainly based on the special microscopic features of the tumor cells (typical Bfried-egg[ appearance), interrupted by a dense network of branching capillaries. We discuss further the pathophysiological mechanisms of death and present a short review of literature.
AB - Sudden and unexpected deaths due to asymptomatic 5 primary brain tumors are extremely rare, with an incidence that ranges from 0.16 to 3.2%. Usually, such tumors are glioblastomas or, less commonly, astrocytomas. Asymptomatic oligodendrogliomas causing sudden death are hardly ever reported among medico-legal investigated cases.We report a rare case of sudden and unexpected death from a previously asymptomatic and undiagnosed, well-differentiated, grade II oligodendrogloioma (WHO classification). According to the autopsy and the microscopic findings brain edema as a result of obstruction of the cerebrospinal fluid flow due to hemorrhagic leakage of the oligodendroglioma is incriminated as the most probable physiopathological mechanism for the sudden death. Diagnosis is mainly based on the special microscopic features of the tumor cells (typical Bfried-egg[ appearance), interrupted by a dense network of branching capillaries. We discuss further the pathophysiological mechanisms of death and present a short review of literature.
U2 - 10.1097/PAF.0b013e3181d3dc86
DO - 10.1097/PAF.0b013e3181d3dc86
M3 - Article
SN - 0195-7910
VL - 32
SP - 336
EP - 340
JO - The American journal of forensic medicine and pathology
JF - The American journal of forensic medicine and pathology
IS - 4
ER -